Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3063957..3064624 Replicon chromosome
Accession NZ_CP075185
Organism Dechloromonas denitrificans strain 110

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KI611_RS14650 Protein ID WP_226416393.1
Coordinates 3063957..3064139 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KI611_RS14655 Protein ID WP_226416394.1
Coordinates 3064226..3064624 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI611_RS14620 (KI611_14590) 3059011..3059325 + 315 WP_226416387.1 phage tail assembly protein -
KI611_RS14625 (KI611_14595) 3059334..3059450 + 117 WP_226416388.1 GpE family phage tail protein -
KI611_RS14630 (KI611_14600) 3059447..3061654 + 2208 WP_226416389.1 phage tail tape measure protein -
KI611_RS14635 (KI611_14605) 3061658..3062074 + 417 WP_226416390.1 hypothetical protein -
KI611_RS14640 (KI611_14610) 3062077..3062535 + 459 WP_226416391.1 phage tail protein -
KI611_RS14645 (KI611_14615) 3062532..3063878 + 1347 WP_226416392.1 contractile injection system protein, VgrG/Pvc8 family -
KI611_RS14650 (KI611_14620) 3063957..3064139 + 183 WP_226416393.1 type II toxin-antitoxin system HicA family toxin Toxin
KI611_RS14655 (KI611_14625) 3064226..3064624 + 399 WP_226416394.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KI611_RS14660 (KI611_14630) 3064760..3065128 - 369 WP_226416395.1 hypothetical protein -
KI611_RS14665 (KI611_14635) 3065137..3065544 - 408 WP_226416396.1 Arc family DNA-binding protein -
KI611_RS14670 (KI611_14640) 3065650..3065826 + 177 WP_226416397.1 Arc family DNA-binding protein -
KI611_RS14675 (KI611_14645) 3065819..3066361 + 543 WP_226416398.1 Bro-N domain-containing protein -
KI611_RS14680 (KI611_14650) 3066704..3066928 + 225 WP_226416399.1 hypothetical protein -
KI611_RS14685 (KI611_14655) 3066925..3067284 - 360 WP_226416400.1 helix-turn-helix domain-containing protein -
KI611_RS14690 (KI611_14660) 3067341..3067592 + 252 WP_226416401.1 hypothetical protein -
KI611_RS14695 (KI611_14665) 3067613..3068197 + 585 WP_226416402.1 hypothetical protein -
KI611_RS14700 (KI611_14670) 3068188..3068469 + 282 WP_226416403.1 ogr/Delta-like zinc finger family protein -
KI611_RS14705 (KI611_14675) 3068552..3068749 + 198 WP_226416404.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3035350..3086252 50902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6701.83 Da        Isoelectric Point: 11.1589

>T203363 WP_226416393.1 NZ_CP075185:3063957-3064139 [Dechloromonas denitrificans]
MNSQKLIRMLEDDGWRQARVAGSHHHFKHPTKPGLVTVPHPKKDLPVGTVNSILKQAGLK

Download         Length: 183 bp

>T203363 NZ_CP099973:3412109-3412327 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14638.40 Da        Isoelectric Point: 4.5616

>AT203363 WP_226416394.1 NZ_CP075185:3064226-3064624 [Dechloromonas denitrificans]
MEFPIAIHKDDGSVYGVTVPDIPGCHSWGDSINEAIRNAKDAIYSHIETLLELGEQADFSASTIDDLTGKEDFVGAIWAL
VEVDFSELDPKPERVNISLPRFVLRRIDEYTKAHHETRSGFLARAAMHALAS

Download         Length: 399 bp

>AT203363 NZ_CP099973:3411707-3412081 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References