Detailed information of TA system TA203361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 4671982..4672691
• Replicon: chromosome
• Accession: NZ_CP075183
• Organism: Hydrogenophaga taeniospiralis strain LT2

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: KI616_RS22170
• Protein ID: WP_226463393.1
• Coordinates: 4672308..4672691 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: KI616_RS22165
• Protein ID: WP_226463392.1
• Coordinates: 4671982..4672311 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI616_RS22155 (KI616_22080)	4667995..4670511	-	2517	WP_226463390.1	Tn3 family transposase	-
KI616_RS22160 (KI616_22085)	4670554..4671870	-	1317	WP_226463391.1	site-specific integrase	-
KI616_RS22165 (KI616_22090)	4671982..4672311	-	330	WP_226463392.1	helix-turn-helix transcriptional regulator	Antitoxin
KI616_RS22170 (KI616_22095)	4672308..4672691	-	384	WP_226463393.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KI616_RS22175 (KI616_22100)	4672981..4674372	-	1392	WP_226463394.1	heavy metal sensor histidine kinase	-
KI616_RS22180 (KI616_22105)	4674372..4675058	-	687	WP_226463395.1	heavy metal response regulator transcription factor	-
KI616_RS22185 (KI616_22110)	4675336..4676310	+	975	WP_226463396.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4556817..4809693	252876

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-90)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14188.28 Da
• Isoelectric Point: 10.1527

>T203361 WP_226463393.1 NZ_CP075183:c4672691-4672308 [Hydrogenophaga taeniospiralis]
MQKQARKPIKWVSSAKRDLDAMPEEVKDIFGHAIDLAQAGGKHKDSKVLTGFGSAGVLEVVEDHQGDTFRAVYTVKFAGW
VYVLHCFQKKSKSGIATPKQDMDLINTRLKAAKQDFEAWQAQQGVRK

Nucleotide

• Length: 384 bp

>T203361 NZ_CP099973:c2444135-2443980 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11886.62 Da
• Isoelectric Point: 10.3684

>AT203361 WP_226463392.1 NZ_CP075183:c4672311-4671982 [Hydrogenophaga taeniospiralis]
MNGHNEITIEEGGTNVYADLGYTDAAEMQRKSQLAGEIARAIKARRLTQEGAATLLGIDQSKVSRITRGQFRGVSEAKLL
ELVARLGHDVKIVVGPVRRRAGKIELQFA

Nucleotide

• Length: 330 bp

>AT203361 NZ_CP099973:2444147-2444205 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA