Detailed information of TA system TA203360

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3309904..3311464
• Replicon: chromosome
• Accession: NZ_CP075183
• Organism: Hydrogenophaga taeniospiralis strain LT2

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: KI616_RS15905
• Protein ID: WP_226462336.1
• Coordinates: 3309904..3311226 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: KI616_RS15910
• Protein ID: WP_226462337.1
• Coordinates: 3311228..3311464 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI616_RS15900 (KI616_15860)	3306174..3309824	-	3651	WP_226462335.1	BREX-1 system adenine-specific DNA-methyltransferase PglX	-
KI616_RS15905 (KI616_15865)	3309904..3311226	-	1323	WP_226462336.1	type II toxin-antitoxin system HipA family toxin	Toxin
KI616_RS15910 (KI616_15870)	3311228..3311464	-	237	WP_226462337.1	helix-turn-helix transcriptional regulator	Antitoxin
KI616_RS15915 (KI616_15875)	3311609..3315223	-	3615	WP_226462338.1	BREX system P-loop protein BrxC	-
KI616_RS15920 (KI616_15880)	3315272..3315859	-	588	WP_226462339.1	DUF1788 domain-containing protein	-
KI616_RS15925 (KI616_15885)	3315856..3316449	-	594	WP_226462340.1	DUF1819 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-66)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 47928.87 Da
• Isoelectric Point: 5.6655

>T203360 WP_226462336.1 NZ_CP075183:c3311226-3309904 [Hydrogenophaga taeniospiralis]
MDRQLEVWLFGNPIGTLTQADGRLAFSYRPEWLAGGQATPLSQSLPLQAEAFDDRATRPFFAGLLPEGDKRRLVAQALGV
SRQNDFALLDGIGGECAGAVTLLEPGQTPSHAAPANAVRWLDDADLLKLLAEMPRRPMLAGDGDLRLSLAGAQDKLPVVV
AGERIGLPLFGSPSTHILKPAIEGIEGSVFNEGFCMALARAMGLDAAPSEIRRVQGQPYLLVQRYDRLPVEQSPAATIQR
LHQEDFCQALGVPPELKYQNEGGPDLAQAFALVRSATRPNAPHILKLLGFVLFNALIGNHDAHAKNFSLLYSPRCAALAP
LYDALSTAVYPDLTDKMAMKIGSKYRFAELHARHWEQFATSAGLSPAQVKKELKRFAERLPDQVRLVRAEFLVTDLLHPV
LSQISELIEDRCATTLRRLAMSPAQAEAETDTPEEEGPAP

Nucleotide

• Length: 1323 bp

>T203360 NZ_CP099973:c989051-988524 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8279.60 Da
• Isoelectric Point: 9.0031

>AT203360 WP_226462337.1 NZ_CP075183:c3311464-3311228 [Hydrogenophaga taeniospiralis]
MSTRIDTPEALGQAVRGARKQLNLTQPQLALAAGVGVRFIVDLEAGKPTLRLENILRVLHALGGELQVDGLPTPREGA

Nucleotide

• Length: 237 bp

>AT203360 NZ_CP099973:c989338-989048 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA