Detailed information of TA system TA203357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 4168614..4170211
• Replicon: chromosome
• Accession: NZ_CP075180
• Organism: Pseudomonas lundensis strain M105

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KIY13_RS19200
• Protein ID: WP_047283339.1
• Coordinates: 4168614..4169939 (+)
• Length: 442 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A1D9ILT1
• Locus tag: KIY13_RS19205
• Protein ID: WP_047283340.1
• Coordinates: 4169936..4170211 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KIY13_RS19185 (KIY13_19185)	4164658..4166466	+	1809	WP_047279057.1	sodium-extruding oxaloacetate decarboxylase subunit alpha	-
KIY13_RS19190 (KIY13_19190)	4166582..4167505	-	924	WP_143007112.1	hypothetical protein	-
KIY13_RS19195 (KIY13_19195)	4167683..4168105	-	423	WP_139047533.1	hypothetical protein	-
KIY13_RS19200 (KIY13_19200)	4168614..4169939	+	1326	WP_047283339.1	HipA domain-containing protein	Toxin
KIY13_RS19205 (KIY13_19205)	4169936..4170211	+	276	WP_047283340.1	helix-turn-helix transcriptional regulator	Antitoxin
KIY13_RS19210 (KIY13_19210)	4170267..4170947	-	681	WP_047283341.1	GNAT family protein	-
KIY13_RS19215 (KIY13_19215)	4170962..4171414	-	453	WP_047283342.1	GNAT family N-acetyltransferase	-
KIY13_RS19220 (KIY13_19220)	4171419..4172048	-	630	WP_047279065.1	FMN-binding negative transcriptional regulator	-
KIY13_RS19225 (KIY13_19225)	4172138..4173685	+	1548	WP_047279705.1	PLP-dependent aminotransferase family protein	-
KIY13_RS19230 (KIY13_19230)	4173732..4174832	-	1101	WP_047281686.1	polyamine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-385)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-82)

Sequences

Toxin

Protein

• Length: 442 a.a.
• Molecular weight: 49584.79 Da
• Isoelectric Point: 6.3244

>T203357 WP_047283339.1 NZ_CP075180:4168614-4169939 [Pseudomonas lundensis]
MFQLTLQLYSDGQWQDAMTLLFPEPEKGFDGPCRFGYKQDYLLQNLDLIDSPFMKSVSARVPLGWDAHNVKKAPAFLHDI
APGGAARKILIKQIGREKPEGLSIDLFLLGRSTPAPIGHLRVKESFERLDTLAPLGFARQDVIDRDNRFLEYAHEQGAAI
GGATGAGGEAPKLLMAQSAEGLLYPDATLADVDVKQHWFIKFARNRALRLDCDILRSEFMYYKALQALGIETVPAQGLAL
EEGRKPSLWMQRFDRKVTAQGVERLAVESMYSLAQVTQAGSDMTHHHVLKLLASLWTQAGQHDEIPDMVADYLRRDLLNK
ILGNSDNHGRNTAIIRDVDALRLAPIYDLAPMVMDDEGITRTTKWSREVERAGQINWRAACESLKEIIDPDSAFERLRAD
AELLRPLPDVLRAQGLPDVTMDHPHIALKHLDQRLREWGLK

Nucleotide

• Length: 1326 bp

>T203357 NZ_CP099973:358942-359217 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10235.09 Da
• Isoelectric Point: 10.8992

>AT203357 WP_047283340.1 NZ_CP075180:4169936-4170211 [Pseudomonas lundensis]
MTVSIDARRLMIEAIEADLARGEITLGDAVKRLRGEVTKLQQTQFARMCKISVRTLIQIEHNEGNPTLKSLNAVFKPFGL
QMGVVRLPRPF

Nucleotide

• Length: 276 bp

>AT203357 NZ_CP099973:358679-358939 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1D9ILT1