Detailed information of TA system TA203354

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3763555..3764775
• Replicon: chromosome
• Accession: NZ_CP075176
• Organism: Pseudomonas aeruginosa strain PA790

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KIK44_RS17585
• Protein ID: WP_003118970.1
• Coordinates: 3764197..3764775 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KIK44_RS17580
• Protein ID: WP_003132728.1
• Coordinates: 3763555..3764109 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KIK44_RS17555 (KIK44_17555)	3759123..3759674	+	552	WP_003132721.1	XRE family transcriptional regulator	-
KIK44_RS17560 (KIK44_17560)	3759671..3760069	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
KIK44_RS17565 (KIK44_17565)	3760082..3760405	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
KIK44_RS17570 (KIK44_17570)	3760736..3761197	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
KIK44_RS17575 (KIK44_17575)	3761202..3763397	+	2196	WP_033938086.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
KIK44_RS17580 (KIK44_17580)	3763555..3764109	+	555	WP_003132728.1	helix-turn-helix transcriptional regulator	Antitoxin
KIK44_RS17585 (KIK44_17585)	3764197..3764775	+	579	WP_003118970.1	HD domain-containing protein	Toxin
KIK44_RS17590 (KIK44_17590)	3764885..3766072	-	1188	WP_003110489.1	HlyD family efflux transporter periplasmic adaptor subunit	-
KIK44_RS17595 (KIK44_17595)	3766062..3768233	-	2172	WP_033989048.1	type I secretion system permease/ATPase	-
KIK44_RS17600 (KIK44_17600)	3768223..3769281	-	1059	WP_223724268.1	TolC family protein	-
KIK44_RS17605 (KIK44_17605)	3769331..3769555	-	225	WP_010791890.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3763555..3807942	44387

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21899.72 Da
• Isoelectric Point: 5.3655

>T203354 WP_003118970.1 NZ_CP075176:3764197-3764775 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T203354 NZ_CP099968:c1236339-1236034 [Brucella pseudintermedia]
ATGCTTACGATCAAACGTACCACTATCTTTATTGATTGGCTCAAGGGTCTGAAAGACCGTCGTGCCGTCGCGCGGATTGC
GATGAGAATTGACAGATTTGAGTCTGGCAACCCCGGTCATGTACGAGATGTTGGCGATGGCGTGGGCGAGATGAAAATCG
ACTATGGGCCGGGCTACCGAGTCTATTATGTCCGCCGCGAAAAGACCATTTATCTATTACTTTGCGGTGGAGACAAGCGA
ACGCAGGACAGAGATATAGCCGAAGCCAAGCGCATCGCAAAGGAGTGGACAGATGAAGAAGATTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20470.63 Da
• Isoelectric Point: 8.1590

>AT203354 WP_003132728.1 NZ_CP075176:3763555-3764109 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT203354 NZ_CP099968:c1236047-1235742 [Brucella pseudintermedia]
ATGAAGAAGATTGAAGTGGCTGCATGGGACAGCGCGGAAGTTCTCGACACGCCCGAGGCCATTGAAGAATACCTTGCCGC
CGCATTTGAGACGGAGGACCCGGTGTTCATCGCCAAGGCGCTCGGCGTCGTTGCCCGCGCTCGCAATATGAGCAAATTGG
CTCGCAATACAGGAATGACACGGGCGGCGCTTTATCGCGCTTTCAACGGCGAGACGAGTCCGGAGTTCGCGACGATCATG
AAGATCATGCATGCGCTAGGCGTCAGCATTACTCCCGTGGTGAAAAAGACCGAGGAAGCGGCTTGA