Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1593123..1594818 | Replicon | chromosome |
| Accession | NZ_CP075176 | ||
| Organism | Pseudomonas aeruginosa strain PA790 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9HYA0 |
| Locus tag | KIK44_RS07395 | Protein ID | WP_003112901.1 |
| Coordinates | 1593123..1593992 (+) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q9HYA1 |
| Locus tag | KIK44_RS07400 | Protein ID | WP_003112902.1 |
| Coordinates | 1593985..1594818 (+) | Length | 278 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KIK44_RS07370 (KIK44_07370) | 1589131..1589982 | + | 852 | WP_003130104.1 | ABC transporter ATP-binding protein | - |
| KIK44_RS07375 (KIK44_07375) | 1590023..1591030 | + | 1008 | WP_023097315.1 | ABC transporter substrate-binding protein | - |
| KIK44_RS07380 (KIK44_07380) | 1591027..1591803 | + | 777 | WP_003112898.1 | ABC transporter permease | - |
| KIK44_RS07385 (KIK44_07385) | 1591809..1592570 | + | 762 | WP_003112899.1 | SDR family oxidoreductase | - |
| KIK44_RS07390 (KIK44_07390) | 1592584..1593114 | + | 531 | WP_003112900.1 | cupin domain-containing protein | - |
| KIK44_RS07395 (KIK44_07395) | 1593123..1593992 | + | 870 | WP_003112901.1 | alpha/beta hydrolase | Toxin |
| KIK44_RS07400 (KIK44_07400) | 1593985..1594818 | + | 834 | WP_003112902.1 | IclR family transcriptional regulator | Antitoxin |
| KIK44_RS07405 (KIK44_07405) | 1594805..1595602 | + | 798 | WP_023111480.1 | SDR family oxidoreductase | - |
| KIK44_RS07410 (KIK44_07410) | 1595595..1597277 | + | 1683 | WP_003130114.1 | thiamine pyrophosphate-binding protein | - |
| KIK44_RS07415 (KIK44_07415) | 1597288..1598091 | + | 804 | WP_003130116.1 | aspartate dehydrogenase | - |
| KIK44_RS07420 (KIK44_07420) | 1598103..1599587 | + | 1485 | WP_023102925.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30403.60 Da Isoelectric Point: 6.5894
>T203352 WP_003112901.1 NZ_CP075176:1593123-1593992 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
Download Length: 870 bp
>T203352 NZ_CP099968:c1236047-1235742 [Brucella pseudintermedia]
ATGAAGAAGATTGAAGTGGCTGCATGGGACAGCGCGGAAGTTCTCGACACGCCCGAGGCCATTGAAGAATACCTTGCCGC
CGCATTTGAGACGGAGGACCCGGTGTTCATCGCCAAGGCGCTCGGCGTCGTTGCCCGCGCTCGCAATATGAGCAAATTGG
CTCGCAATACAGGAATGACACGGGCGGCGCTTTATCGCGCTTTCAACGGCGAGACGAGTCCGGAGTTCGCGACGATCATG
AAGATCATGCATGCGCTAGGCGTCAGCATTACTCCCGTGGTGAAAAAGACCGAGGAAGCGGCTTGA
ATGAAGAAGATTGAAGTGGCTGCATGGGACAGCGCGGAAGTTCTCGACACGCCCGAGGCCATTGAAGAATACCTTGCCGC
CGCATTTGAGACGGAGGACCCGGTGTTCATCGCCAAGGCGCTCGGCGTCGTTGCCCGCGCTCGCAATATGAGCAAATTGG
CTCGCAATACAGGAATGACACGGGCGGCGCTTTATCGCGCTTTCAACGGCGAGACGAGTCCGGAGTTCGCGACGATCATG
AAGATCATGCATGCGCTAGGCGTCAGCATTACTCCCGTGGTGAAAAAGACCGAGGAAGCGGCTTGA
Antitoxin
Download Length: 278 a.a. Molecular weight: 30877.26 Da Isoelectric Point: 5.7725
>AT203352 WP_003112902.1 NZ_CP075176:1593985-1594818 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
Download Length: 834 bp
>AT203352 NZ_CP099968:c1235668-1235345 [Brucella pseudintermedia]
ATGATCGAAGTCATTCATGGAAGTCAGAATGTCTATGCCGATCTGGGCTTTCCAGATGCAGAGGAAATGTTTGTTAAGGC
CAAGCTGGTGACGAAAATTCGTCAGATAATCAAAGATCGCGGCTGGACCCAAAAGCAGGCCGGGACGGTTCTGGGTATGC
CTCAGCCGAAGCTCTCAAAGATGCTCAATGGACAGTTCCGGGGTATTAGTGAAGCTAAAATGCTTGAATGCCTCGCGCGC
CTTGGTCGTGATGTTCAGATTGTTGTAGGGCCGGAACGAGATTCGACGGAAGCCGGTCACGTCAATGTGGTCTTTGCTGC
GTAA
ATGATCGAAGTCATTCATGGAAGTCAGAATGTCTATGCCGATCTGGGCTTTCCAGATGCAGAGGAAATGTTTGTTAAGGC
CAAGCTGGTGACGAAAATTCGTCAGATAATCAAAGATCGCGGCTGGACCCAAAAGCAGGCCGGGACGGTTCTGGGTATGC
CTCAGCCGAAGCTCTCAAAGATGCTCAATGGACAGTTCCGGGGTATTAGTGAAGCTAAAATGCTTGAATGCCTCGCGCGC
CTTGGTCGTGATGTTCAGATTGTTGTAGGGCCGGAACGAGATTCGACGGAAGCCGGTCACGTCAATGTGGTCTTTGCTGC
GTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|