Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 3341684..3342319 Replicon chromosome
Accession NZ_CP075175
Organism Paenibacillus sp. 481

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag KIK04_RS14800 Protein ID WP_232274415.1
Coordinates 3341969..3342319 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KIK04_RS14795 Protein ID WP_232274414.1
Coordinates 3341684..3341965 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIK04_RS14780 (KIK04_14845) 3337564..3337746 - 183 Protein_2872 transposase -
KIK04_RS14785 (KIK04_14850) 3338582..3340024 + 1443 WP_232274413.1 DUF4367 domain-containing protein -
KIK04_RS14790 (KIK04_14855) 3340234..3341457 + 1224 WP_232278745.1 alanine racemase -
KIK04_RS14795 (KIK04_14860) 3341684..3341965 + 282 WP_232274414.1 ribbon-helix-helix protein, CopG family Antitoxin
KIK04_RS14800 (KIK04_14865) 3341969..3342319 + 351 WP_232274415.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KIK04_RS14805 (KIK04_14870) 3342479..3344698 + 2220 WP_269670948.1 Tex family protein -
KIK04_RS14810 (KIK04_14875) 3344880..3345020 - 141 WP_232274416.1 cortex morphogenetic protein CmpA -
KIK04_RS14815 (KIK04_14880) 3345210..3345566 - 357 WP_232274417.1 hydrolase/acyltransferase -
KIK04_RS14820 (KIK04_14885) 3345751..3346269 + 519 WP_232278747.1 SprT family protein -
KIK04_RS14825 (KIK04_14890) 3346315..3347142 + 828 WP_232274418.1 uroporphyrinogen-III synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12878.79 Da        Isoelectric Point: 4.8728

>T203350 WP_232274415.1 NZ_CP075175:3341969-3342319 [Paenibacillus sp. 481]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAETHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMRKVDDGLQISIGLIDF

Download         Length: 351 bp

>T203350 NZ_CP099965:3830375-3830668 [Halomonas sp. DN3]
ATGGTGAAGATTGAGTGGTCAATCTTGGCGCTTAAAGACGCATCAGGGATTGTTGAATACATTTCTGAAGACACCCCTGA
TGCGGCTCTAAAACTCTTCCATCATATAAAGAACAAGGTAGATCGTCTCCCTGACCATCCAAAGCTGTATAAACCAGGAA
GGGAGCCTCGAACACGCGAGATGGTTGTCACAGATAACTACATCGTTGTTTACCGAGAGTCTGAAGCATTGATTACCATC
TTGCGGGTGCTGCATGCTGCGCAAAAAATGGCCTTAGAATCGAAAAAGGAATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10652.32 Da        Isoelectric Point: 8.4934

>AT203350 WP_232274414.1 NZ_CP075175:3341684-3341965 [Paenibacillus sp. 481]
VANIQNTKRIMISLPDQLLQEVDGIVAMEKSNRSEFIRQAMKLYLSERKKRHIRESMQRGYMEMAKINLTMASEAFYAEE
DADGTLGRLVSGV

Download         Length: 282 bp

>AT203350 NZ_CP099965:3830092-3830388 [Halomonas sp. DN3]
ATGGCCCGCACAACGATGCTGCATGTTCGAGTGGACGAAGATCTGAAAGCAGAAGCCACTGAAACTCTTGCGAAAGTGGG
TCTTACGGTGTCGGAGGCTGTACGGATTCTCCTGACACGGGTTAGCGCCGAAGGAGGGCTGCCAGCGGGACTCACCAGTG
ACCCCCAGGCGCATGATGCTTGGTTTCGCATGAAGGTACAGGAGGCGCTGGCTGATACACGCCAGGGCATCCCACACGAT
CACGCAATGAGCCATATCCAGGCCATTATAGAGAGCAAGCGCAATGGTGAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References