203348

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4004211..4004854 Replicon chromosome
Accession NZ_CP075174
Organism Salmonella enterica subsp. houtenae serovar 45:gz51:- strain 20-369

Toxin (Protein)


Gene name vagD Uniprot ID A0A727TKN0
Locus tag KI721_RS19300 Protein ID WP_002955045.1
Coordinates 4004438..4004854 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A727TKY4
Locus tag KI721_RS19295 Protein ID WP_024159961.1
Coordinates 4004211..4004441 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI721_RS19285 (4001257) 4001257..4003395 + 2139 WP_000187810.1 anaerobic ribonucleoside-triphosphate reductase -
KI721_RS19290 (4003580) 4003580..4004044 + 465 WP_001210950.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KI721_RS19295 (4004211) 4004211..4004441 + 231 WP_024159961.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KI721_RS19300 (4004438) 4004438..4004854 + 417 WP_002955045.1 type II toxin-antitoxin system VapC family toxin Toxin
KI721_RS19305 (4004915) 4004915..4006828 - 1914 WP_001212155.1 BglG family transcription antiterminator -
KI721_RS19310 (4006845) 4006845..4007585 - 741 WP_002955043.1 KDGP aldolase family protein -
KI721_RS19315 (4007582) 4007582..4008700 - 1119 WP_001139195.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
KI721_RS19320 (4008684) 4008684..4009817 - 1134 WP_000459960.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15189.50 Da        Isoelectric Point: 8.1468

>T203348 WP_002955045.1 NZ_CP075174:4004438-4004854 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
MSKTYMLDTCICSFIMREQPEAVLKHLEQTVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQRVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T203348 NZ_CP099965:2186328-2186552 [Halomonas sp. DN3]
GTGATCAGCTACATTGCAGAACGTGATCCCCAGGCGGCTCTGCGACTTCGCAGTAGACTCGAATCTGCTGTTACCTCGGT
TGCCGAGCACCCTTTCCTCCATCAAGTAGGGCGGGTTCCCGGTACACGGGAGATAGTGGTCCACCCCAACTTTATCGTGA
TCTATCAGGTAACGGATCGCATCGAAGTTACCGCAGTGGTTCACGCTCGCCAGAATTATCCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8905.93 Da        Isoelectric Point: 4.6794

>AT203348 WP_024159961.1 NZ_CP075174:4004211-4004441 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
MRTVSVFKNGNNRAIRLPRDLDFEGVNELEIFREGDTIILRPARPSWGSFRHEEKANPDFLTEREDIVSDEGRFEL

Download         Length: 231 bp

>AT203348 NZ_CP099965:2186083-2186280 [Halomonas sp. DN3]
ATGACCACCAAGCTGGATCCGATAATTTCCGAGTTCGAGACGCAGGAGCAGGCGGAGAGCCATGATCGCTGGTTGCGTGA
AAAGGTTCAGCGCAGCATCGATCATCCAGGCCAGGGAATGTCTCATGATCAGGTCATGGCCAAGGTCGACATCATCATCA
ACGATGCGAGGAAGCGACGCGGTGGCGAAGAGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A727TKN0

Antitoxin

Source ID Structure
AlphaFold DB A0A727TKY4

References