Detailed information of TA system TA203346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 3909814..3910390
• Replicon: chromosome
• Accession: NZ_CP075174
• Organism: Salmonella enterica subsp. houtenae serovar 45:gz51:- strain 20-369

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: -
• Locus tag: KI721_RS18860
• Protein ID: WP_079811695.1
• Coordinates: 3910103..3910390 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: B5R9R5
• Locus tag: KI721_RS18855
• Protein ID: WP_000063142.1
• Coordinates: 3909814..3910116 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI721_RS18840 (3906324)	3906324..3908474	+	2151	WP_079811694.1	pyruvate/proton symporter BtsT	-
KI721_RS18845 (3908569)	3908569..3908772	+	204	WP_000460616.1	YbdD/YjiX family protein	-
KI721_RS18850 (3908783)	3908783..3909739	+	957	WP_000187838.1	GTPase	-
KI721_RS18855 (3909814)	3909814..3910116	-	303	WP_000063142.1	BrnA antitoxin family protein	Antitoxin
KI721_RS18860 (3910103)	3910103..3910390	-	288	WP_079811695.1	BrnT family toxin	Toxin
KI721_RS18865 (3910659)	3910659..3911573	-	915	WP_000290515.1	restriction endonuclease	-
KI721_RS18870 (3911771)	3911771..3915280	+	3510	WP_079811696.1	type I restriction-modification system endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (37-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11340.89 Da
• Isoelectric Point: 8.9866

>T203346 WP_079811695.1 NZ_CP075174:c3910390-3910103 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
MPMEFEWDANKAKSNLRKHCVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Nucleotide

• Length: 288 bp

>T203346 NZ_CP099914:c3966504-3966163 [Escherichia albertii]
ATGAAAATTATACCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCGCCTGTCGTGGTCTGGCAAACATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ATGCCGGAATCACTTTGGTTGATGCCATCAATTTTTTGGTGGAGAAGTACCAATTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTACGGGCGCGGCAGGCTACAGGTCTGCTGCGCCGCTG
CCATAACACGGCGACACGGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11373.96 Da
• Isoelectric Point: 10.1293

>AT203346 WP_000063142.1 NZ_CP075174:c3910116-3909814 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Nucleotide

• Length: 303 bp

>AT203346 NZ_CP099914:c3966870-3966535 [Escherichia albertii]
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTTACACCACGCTTCACTGCACGACTGGT
ACAGGAAAGACATAACCTGAATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTCCCGGTGCTGATGAAACAACGGGAGCTGAAACTGGCTGACGGTGAACTCTCCCCCTGCCAACAACGT
ACCGTCACGCTACACGCCAAAGGGCTGACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCATTCAACGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A4D6PB01