203345

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3407888..3408508 Replicon chromosome
Accession NZ_CP075174
Organism Salmonella enterica subsp. houtenae serovar 45:gz51:- strain 20-369

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KI721_RS16515 Protein ID WP_001280991.1
Coordinates 3408290..3408508 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag KI721_RS16510 Protein ID WP_000344807.1
Coordinates 3407888..3408262 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI721_RS16500 (3403025) 3403025..3404218 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KI721_RS16505 (3404241) 3404241..3407390 + 3150 WP_001132514.1 efflux RND transporter permease AcrB -
KI721_RS16510 (3407888) 3407888..3408262 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
KI721_RS16515 (3408290) 3408290..3408508 + 219 WP_001280991.1 HHA domain-containing protein Toxin
KI721_RS16520 (3408688) 3408688..3409239 + 552 WP_079807183.1 maltose O-acetyltransferase -
KI721_RS16525 (3409356) 3409356..3409826 + 471 WP_000136184.1 YlaC family protein -
KI721_RS16530 (3409881) 3409881..3410021 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
KI721_RS16535 (3410027) 3410027..3410287 - 261 WP_000801413.1 type B 50S ribosomal protein L31 -
KI721_RS16540 (3410512) 3410512..3412062 + 1551 WP_000213151.1 EAL domain-containing protein -
KI721_RS16550 (3412293) 3412293..3412682 + 390 WP_079812228.1 MGMT family protein -
KI721_RS16555 (3412715) 3412715..3413284 - 570 WP_000779808.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T203345 WP_001280991.1 NZ_CP075174:3408290-3408508 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T203345 NZ_CP099914:3899353-3899694 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTAAATTAACCGTAAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCACCCAACCACCCGCCACCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTAATTAC
AGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT203345 WP_000344807.1 NZ_CP075174:3407888-3408262 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT203345 NZ_CP099914:c3899358-3899282 [Escherichia albertii]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References