203344

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 2279315..2280072 Replicon chromosome
Accession NZ_CP075174
Organism Salmonella enterica subsp. houtenae serovar 45:gz51:- strain 20-369

Toxin (Protein)


Gene name tacT Uniprot ID A0A727YYP2
Locus tag KI721_RS11015 Protein ID WP_000406362.1
Coordinates 2279590..2280072 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A727Z1I8
Locus tag KI721_RS11010 Protein ID WP_001195098.1
Coordinates 2279315..2279599 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI721_RS10985 (2274361) 2274361..2274936 + 576 WP_079812162.1 YceI family protein -
KI721_RS10990 (2274948) 2274948..2276150 + 1203 WP_000856052.1 lactate oxidase -
KI721_RS10995 (2276197) 2276197..2276634 - 438 WP_000354864.1 cryptic aminoglycoside N-acetyltransferase AAC(6')-Iy/Iaa -
KI721_RS11000 (2276634) 2276634..2277425 - 792 WP_024134767.1 DeoR/GlpR family DNA-binding transcription regulator -
KI721_RS11005 (2277440) 2277440..2277862 - 423 Protein_2152 epimerase -
KI721_RS11010 (2279315) 2279315..2279599 + 285 WP_001195098.1 DUF1778 domain-containing protein Antitoxin
KI721_RS11015 (2279590) 2279590..2280072 + 483 WP_000406362.1 GNAT family N-acetyltransferase Toxin
KI721_RS11020 (2280077) 2280077..2280183 - 107 Protein_2155 ethanolamine utilization protein EutE -
KI721_RS11025 (2280464) 2280464..2280913 + 450 WP_000750480.1 hypothetical protein -
KI721_RS11030 (2280969) 2280969..2281055 - 87 Protein_2157 hypothetical protein -
KI721_RS11035 (2281132) 2281132..2281470 + 339 WP_001664011.1 hypothetical protein -
KI721_RS11040 (2281467) 2281467..2281595 + 129 Protein_2159 IS66 family insertion sequence element accessory protein TnpB -
KI721_RS11045 (2281849) 2281849..2282850 + 1002 WP_000559544.1 IS110 family transposase -
KI721_RS11050 (2282931) 2282931..2283962 + 1032 WP_134953950.1 IS630 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn aac(6')-Iaa - 2276197..2283962 7765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-148)

Antitoxin

Vibrio phage ICP1, Orf50

(13-88)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 18116.77 Da        Isoelectric Point: 7.0279

>T203344 WP_000406362.1 NZ_CP075174:2279590-2280072 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
MEISVTAPELLHEEHDLQQFDCGNDVLSDWLRRRAMKNQYLNASRTFVICLECTKRVVGYYSIATGSVSHASLGRRLRQN
MPDPVPVVLLGRLAVDECTQGHSFGKWLLNDAVTRISNLADQVGIKAIMVHAIDEQAKTFYEYFGFVHSPISPNTLFYKI

Download         Length: 483 bp

>T203344 NZ_CP099914:3824748-3824900 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10964.52 Da        Isoelectric Point: 9.6539

>AT203344 WP_001195098.1 NZ_CP075174:2279315-2279599 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
MQTTIRKSVRNKQINIRATDEERAVIDYAASLVSKNRTDFIIEKAVSEAQNIILDQRVFVLDDARYQAFIKQLEAPVQNT
EGRQRLMDVKPEWK

Download         Length: 285 bp

>AT203344 NZ_CP099914:c3824699-3824642 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A727YYP2

Antitoxin

Source ID Structure
AlphaFold DB A0A727Z1I8

References