Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 788841..789501 Replicon chromosome
Accession NZ_CP075174
Organism Salmonella enterica subsp. houtenae serovar 45:gz51:- strain 20-369

Toxin (Protein)


Gene name cptA Uniprot ID A0A727YNG4
Locus tag KI721_RS03750 Protein ID WP_000244760.1
Coordinates 789088..789501 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag KI721_RS03745 Protein ID WP_000351186.1
Coordinates 788841..789107 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI721_RS03725 (784780) 784780..786213 - 1434 WP_001230137.1 6-phospho-beta-glucosidase -
KI721_RS03730 (786370) 786370..786681 + 312 WP_001182974.1 N(4)-acetylcytidine aminohydrolase -
KI721_RS03735 (786845) 786845..787504 + 660 WP_000250290.1 hemolysin III family protein -
KI721_RS03740 (787612) 787612..788592 - 981 WP_002954437.1 tRNA-modifying protein YgfZ -
KI721_RS03745 (788841) 788841..789107 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
KI721_RS03750 (789088) 789088..789501 + 414 WP_000244760.1 protein YgfX Toxin
KI721_RS03755 (789554) 789554..790075 - 522 WP_001055884.1 flavodoxin FldB -
KI721_RS03760 (790188) 790188..791084 + 897 WP_233679861.1 site-specific tyrosine recombinase XerD -
KI721_RS03765 (791108) 791108..791821 + 714 WP_000745620.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KI721_RS03770 (791827) 791827..793560 + 1734 WP_079812088.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16318.35 Da        Isoelectric Point: 11.1741

>T203332 WP_000244760.1 NZ_CP075174:789088-789501 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRIMLQQPISRQH

Download         Length: 414 bp

>T203332 NZ_CP099914:c253416-253126 [Escherichia albertii]
ATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAAGATACCTTCTGA
TATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACGACCTGGAAGGACTTGAGATCACCACCAGGTA
ATCGGTATGAGGAATTGTCAGGGAAGCTAAACTGCTATTCATCAATAAGGGTGAATAATCAATATAGGTTAATTTTTAAG
TGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT203332 WP_000351186.1 NZ_CP075174:788841-789107 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT203332 NZ_CP099914:c253054-252716 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A727YNG4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References