Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2510598..2511004 Replicon chromosome
Accession NZ_CP075171
Organism Leptodesmis sichuanensis PKUAC-SCTA121

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KIK02_RS11625 Protein ID WP_233748718.1
Coordinates 2510810..2511004 (-) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KIK02_RS11620 Protein ID WP_233748717.1
Coordinates 2510598..2510813 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIK02_RS11560 2505778..2505999 - 222 Protein_2299 IS701 family transposase -
KIK02_RS11565 2506117..2506407 + 291 WP_233748707.1 hypothetical protein -
KIK02_RS11570 2506349..2506927 + 579 WP_233748708.1 hypothetical protein -
KIK02_RS11575 2506906..2507163 + 258 WP_233748709.1 hypothetical protein -
KIK02_RS11580 (KIK02_11660) 2507254..2507466 - 213 WP_233748710.1 DUF2283 domain-containing protein -
KIK02_RS11585 (KIK02_11665) 2507633..2507971 - 339 WP_233748711.1 nucleotidyltransferase family protein -
KIK02_RS11590 (KIK02_11670) 2508134..2508478 - 345 WP_233748712.1 XisI protein -
KIK02_RS11595 (KIK02_11675) 2508466..2508879 - 414 Protein_2306 XisH family protein -
KIK02_RS11600 (KIK02_11680) 2508905..2509255 - 351 WP_233748713.1 DUF86 domain-containing protein -
KIK02_RS11605 (KIK02_11685) 2509245..2509670 - 426 WP_233748714.1 nucleotidyltransferase family protein -
KIK02_RS11610 (KIK02_11690) 2509660..2510013 - 354 WP_233748715.1 DUF86 domain-containing protein -
KIK02_RS11615 (KIK02_11695) 2510003..2510341 - 339 WP_233748716.1 nucleotidyltransferase family protein -
KIK02_RS11620 2510598..2510813 - 216 WP_233748717.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KIK02_RS11625 2510810..2511004 - 195 WP_233748718.1 type II toxin-antitoxin system HicA family toxin Toxin
KIK02_RS11630 (KIK02_11710) 2511744..2511980 - 237 WP_233748719.1 DUF433 domain-containing protein -
KIK02_RS11635 (KIK02_11715) 2512077..2512526 - 450 WP_233748720.1 DUF29 domain-containing protein -
KIK02_RS11640 (KIK02_11720) 2512543..2512992 - 450 WP_233748721.1 DUF29 domain-containing protein -
KIK02_RS11645 (KIK02_11725) 2512997..2513461 - 465 WP_233748722.1 DUF29 domain-containing protein -
KIK02_RS11650 (KIK02_11730) 2513631..2514260 - 630 WP_233748723.1 hypothetical protein -
KIK02_RS11655 (KIK02_11735) 2514305..2514763 - 459 WP_233748724.1 hypothetical protein -
KIK02_RS11660 (KIK02_11740) 2514770..2514988 - 219 WP_233748725.1 hypothetical protein -
KIK02_RS11665 (KIK02_11745) 2515059..2515301 - 243 Protein_2320 phospholipase D-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-62)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7226.35 Da        Isoelectric Point: 9.8657

>T203329 WP_233748718.1 NZ_CP075171:c2511004-2510810 [Leptodesmis sichuanensis PKUAC-SCTA121]
MKVRDVLKRLEADGWYQIRMRGSHRILAHETKSGIVVVPGKPGDEIPKGTLASIWKQAQLEDES

Download         Length: 195 bp

>T203329 NZ_CP099912:4247650-4248027 [Escherichia albertii]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7763.76 Da        Isoelectric Point: 3.7341

>AT203329 WP_233748717.1 NZ_CP075171:c2510813-2510598 [Leptodesmis sichuanensis PKUAC-SCTA121]
MKEYAVIYEQGETNWGAIVPDLPGCVSIGDTFEEVQENVKEAIELYLEVLQERGEPIPEPTTKVGLVGVAA

Download         Length: 216 bp

>AT203329 NZ_CP099912:4247192-4247560 [Escherichia albertii]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References