Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 1654011..1654507 Replicon chromosome
Accession NZ_CP075171
Organism Leptodesmis sichuanensis PKUAC-SCTA121

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KIK02_RS07770 Protein ID WP_233748032.1
Coordinates 1654011..1654286 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KIK02_RS07775 Protein ID WP_233748033.1
Coordinates 1654283..1654507 (-) Length 75 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIK02_RS07725 (KIK02_07800) 1649071..1650213 - 1143 WP_233748028.1 GUN4 domain-containing protein -
KIK02_RS07730 (KIK02_07805) 1650338..1650610 - 273 WP_233748029.1 type II toxin-antitoxin system RelE/ParE family toxin -
KIK02_RS07735 (KIK02_07810) 1650607..1650843 - 237 WP_233748030.1 hypothetical protein -
KIK02_RS07740 (KIK02_07815) 1651231..1651461 + 231 Protein_1543 IS982 family transposase -
KIK02_RS07745 (KIK02_07820) 1651531..1652414 + 884 WP_233748031.1 IS630 family transposase -
KIK02_RS07750 (KIK02_07825) 1652407..1653060 + 654 Protein_1545 IS982 family transposase -
KIK02_RS07755 1653035..1653163 + 129 Protein_1546 HNH endonuclease signature motif containing protein -
KIK02_RS07760 1653191..1653388 + 198 WP_233749051.1 hypothetical protein -
KIK02_RS07765 (KIK02_07835) 1653731..1653916 - 186 Protein_1548 DUF5615 family PIN-like protein -
KIK02_RS07770 (KIK02_07840) 1654011..1654286 - 276 WP_233748032.1 DUF5615 family PIN-like protein Toxin
KIK02_RS07775 (KIK02_07845) 1654283..1654507 - 225 WP_233748033.1 DUF433 domain-containing protein Antitoxin
KIK02_RS07780 (KIK02_07850) 1654666..1655946 - 1281 WP_233748034.1 GUN4 domain-containing protein -
KIK02_RS07785 (KIK02_07855) 1656161..1656370 + 210 WP_233748035.1 hypothetical protein -
KIK02_RS07790 (KIK02_07860) 1656371..1656784 + 414 WP_233748036.1 HNH endonuclease signature motif containing protein -
KIK02_RS07795 (KIK02_07870) 1657177..1657743 - 567 WP_233748037.1 Uma2 family endonuclease -
KIK02_RS07800 (KIK02_07875) 1658154..1658366 - 213 WP_233748038.1 hypothetical protein -
KIK02_RS07805 (KIK02_07880) 1658370..1658696 - 327 WP_233748039.1 hypothetical protein -
KIK02_RS07810 (KIK02_07885) 1659212..1659427 + 216 WP_233748040.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1651920..1652414 494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-53)

Antitoxin

(8-63)


Sequences


Toxin        


Download         Length: 92 a.a.        Molecular weight: 9827.14 Da        Isoelectric Point: 4.6062

>T203328 WP_233748032.1 NZ_CP075171:c1654286-1654011 [Leptodesmis sichuanensis PKUAC-SCTA121]
MKIWVDAQLSPAIATWISSTFGVTALALRDIGLRDAEDPEIFEAAKAQGVIFIPHSALSTGTSGINDAATDSQKPWPEIY
LNKQHLFSTAL

Download         Length: 276 bp

>T203328 NZ_CP099912:4034574-4034915 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGATAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCCCCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAATTTATTGGGGTGATTGC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8116.49 Da        Isoelectric Point: 6.9465

>AT203328 WP_233748033.1 NZ_CP075171:c1654507-1654283 [Leptodesmis sichuanensis PKUAC-SCTA121]
MSDLPKRITVNPNQCGGRPCIRGMRIRVSDVLDLFAAGLSAEQILEEMPDLEANDLKAALLYASRKLNHPVLVA

Download         Length: 225 bp

>AT203328 NZ_CP099912:c4034579-4034503 [Escherichia albertii]
AGTCATGATTACTATTCTCCATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References