Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 585238..585878 Replicon chromosome
Accession NZ_CP075171
Organism Leptodesmis sichuanensis PKUAC-SCTA121

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KIK02_RS02880 Protein ID WP_233746325.1
Coordinates 585238..585636 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KIK02_RS02885 Protein ID WP_233746327.1
Coordinates 585633..585878 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIK02_RS02850 (KIK02_02890) 580671..581465 + 795 WP_233746313.1 nickel pincer cofactor biosynthesis protein LarB -
KIK02_RS02855 (KIK02_02895) 581525..582211 - 687 WP_233746315.1 DUF6391 domain-containing protein -
KIK02_RS02860 (KIK02_02900) 582327..583097 - 771 WP_233746317.1 DUF4079 domain-containing protein -
KIK02_RS02865 (KIK02_02905) 583181..583354 - 174 WP_233746319.1 hypothetical protein -
KIK02_RS02870 (KIK02_02910) 583482..584471 + 990 WP_233746321.1 zinc-dependent alcohol dehydrogenase family protein -
KIK02_RS02875 (KIK02_02915) 584548..585000 - 453 WP_233746323.1 PTPA-CTERM sorting domain-containing protein -
KIK02_RS02880 (KIK02_02920) 585238..585636 - 399 WP_233746325.1 type II toxin-antitoxin system VapC family toxin Toxin
KIK02_RS02885 (KIK02_02925) 585633..585878 - 246 WP_233746327.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KIK02_RS02890 (KIK02_02930) 586120..587343 + 1224 WP_233746329.1 geranylgeranyl reductase -
KIK02_RS02895 (KIK02_02935) 587632..588006 + 375 WP_233746331.1 hypothetical protein -
KIK02_RS02900 (KIK02_02940) 588114..588410 - 297 WP_233746333.1 exodeoxyribonuclease VII small subunit -
KIK02_RS02905 (KIK02_02945) 588482..589735 - 1254 WP_233746343.1 exodeoxyribonuclease VII large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-41)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14993.34 Da        Isoelectric Point: 5.1016

>T203327 WP_233746325.1 NZ_CP075171:c585636-585238 [Leptodesmis sichuanensis PKUAC-SCTA121]
VKLLLDTQCWLWWFAQPDCLNEEAISHIADETNELWLSVASIWEMGIKVSIGKLPLPDPIDSYVPRRMAQLGTRPLEIKA
SHAIQIASLPLHHRDPFDRILISQAQLEKLTLVTADAIFHQYDVAILWAANS

Download         Length: 399 bp

>T203327 NZ_CP099912:3945726-3945878 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9161.36 Da        Isoelectric Point: 5.6631

>AT203327 WP_233746327.1 NZ_CP075171:c585878-585633 [Leptodesmis sichuanensis PKUAC-SCTA121]
METVNIHQAKSNLSRLLSRVEMGEEIIISNRGIPVAKLVPFRPTTHRRDSLGCDRDRFTVPDNFNDPLPEDILAAFEGQQ
S

Download         Length: 246 bp

>AT203327 NZ_CP099912:c3945677-3945620 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References