Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT_toxin-BrnA
Location 358285..358801 Replicon chromosome
Accession NZ_CP075171
Organism Leptodesmis sichuanensis PKUAC-SCTA121

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag KIK02_RS01800 Protein ID WP_233745978.1
Coordinates 358285..358560 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID -
Locus tag KIK02_RS01805 Protein ID WP_233745979.1
Coordinates 358580..358801 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIK02_RS01785 (KIK02_01820) 355776..356015 + 240 WP_193968148.1 UPF0175 family protein -
KIK02_RS01790 (KIK02_01825) 356012..356500 + 489 WP_233745974.1 DUF3368 domain-containing protein -
KIK02_RS01795 (KIK02_01830) 356888..358198 + 1311 WP_233745976.1 IS701 family transposase -
KIK02_RS01800 (KIK02_01835) 358285..358560 + 276 WP_233745978.1 BrnT family toxin Toxin
KIK02_RS01805 (KIK02_01840) 358580..358801 + 222 WP_233745979.1 BrnA antitoxin family protein Antitoxin
KIK02_RS01810 (KIK02_01845) 358806..359417 + 612 WP_233745980.1 hypothetical protein -
KIK02_RS01815 (KIK02_01850) 359657..360097 - 441 Protein_361 transposase -
KIK02_RS01820 (KIK02_01855) 360187..360345 - 159 Protein_362 IS701 family transposase -
KIK02_RS01825 (KIK02_01860) 360339..360866 - 528 WP_233745981.1 tetratricopeptide repeat protein -
KIK02_RS01830 (KIK02_01865) 361049..362077 - 1029 WP_233745982.1 DMT family transporter -
KIK02_RS01835 (KIK02_01870) 362149..363348 + 1200 WP_233745983.1 HhoA/HhoB/HtrA family serine endopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 356888..358198 1310
- inside Integron - - 356012..359881 3869


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(10-68)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10708.97 Da        Isoelectric Point: 5.1679

>T203326 WP_233745978.1 NZ_CP075171:358285-358560 [Leptodesmis sichuanensis PKUAC-SCTA121]
MEYEWDEAKRLANLRKHGIDFIDVPAIFGGDTVTVEDDRYSYGEQRFITFGLLQGRVIAVVHTEREDYTRIISARKATKY
EQRAYFEQLSN

Download         Length: 276 bp

>T203326 NZ_CP099912:3464598-3464816 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8430.60 Da        Isoelectric Point: 5.7783

>AT203326 WP_233745979.1 NZ_CP075171:358580-358801 [Leptodesmis sichuanensis PKUAC-SCTA121]
MTDEDIDFSDCPEVTPEMFAKAIVRRGLPVAKAKTQVTLRIDSDVLDWFKSQGRGYQTQINQLLRAYMEAHQR

Download         Length: 222 bp

>AT203326 NZ_CP099912:3464198-3464572 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References