Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 349958..350661 Replicon chromosome
Accession NZ_CP075171
Organism Leptodesmis sichuanensis PKUAC-SCTA121

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag KIK02_RS01770 Protein ID WP_233745968.1
Coordinates 350284..350661 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag KIK02_RS01765 Protein ID WP_233745966.1
Coordinates 349958..350281 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIK02_RS01730 (KIK02_01765) 345116..345367 + 252 WP_233745954.1 UPF0175 family protein -
KIK02_RS01735 (KIK02_01770) 345364..345852 + 489 WP_233745956.1 DUF3368 domain-containing protein -
KIK02_RS01740 (KIK02_01775) 346122..347012 - 891 WP_233743478.1 IS982 family transposase -
KIK02_RS01745 (KIK02_01780) 347042..348082 - 1041 WP_233745958.1 IS630 family transposase -
KIK02_RS01750 (KIK02_01785) 348240..349100 + 861 WP_233745960.1 restriction endonuclease -
KIK02_RS01755 (KIK02_01790) 349116..349358 + 243 WP_233745962.1 hypothetical protein -
KIK02_RS01760 (KIK02_01795) 349345..349797 + 453 WP_233745964.1 HNH endonuclease -
KIK02_RS01765 (KIK02_01800) 349958..350281 - 324 WP_233745966.1 helix-turn-helix transcriptional regulator Antitoxin
KIK02_RS01770 (KIK02_01805) 350284..350661 - 378 WP_233745968.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KIK02_RS01775 (KIK02_01810) 350920..351240 + 321 WP_233745970.1 CU044_2847 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 349345..351240 1895


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-89)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14066.03 Da        Isoelectric Point: 8.7627

>T203325 WP_233745968.1 NZ_CP075171:c350661-350284 [Leptodesmis sichuanensis PKUAC-SCTA121]
MNALPKPVEWVGSSLEDLKEFPEDVRQTVGYALYLAQCGEKHPSAKPLKGFRGTGVLEIVENFDGDTYRAVYTVKLAGVV
YVLHAFQKKSKQGIATPKQDIDLIEARLKRAKEHYSQNYSKHQGE

Download         Length: 378 bp

>T203325 NZ_CP099912:2427402-2427680 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11480.16 Da        Isoelectric Point: 5.8317

>AT203325 WP_233745966.1 NZ_CP075171:c350281-349958 [Leptodesmis sichuanensis PKUAC-SCTA121]
MTEEIGVQASSGNVFADLSLENADELLVKAELARRISSIITTQQMTQIEAAEALGIDQPKISALINGKLAGFSTARLFRF
LNALGRDVEIVVKPKSHAQAQTRVVAS

Download         Length: 324 bp

>AT203325 NZ_CP099912:2427680-2427964 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References