Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5887041..5887639 Replicon chromosome
Accession NZ_CP075169
Organism Sodalis ligni strain dw23

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GTU79_RS27345 Protein ID WP_203520355.1
Coordinates 5887041..5887421 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GTU79_RS27350 Protein ID WP_214513546.1
Coordinates 5887418..5887639 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU79_RS27320 (GTU79_27305) 5882914..5883144 + 231 Protein_5409 restriction endonuclease subunit S -
GTU79_RS27325 (GTU79_27310) 5883405..5883701 - 297 WP_203520363.1 hypothetical protein -
GTU79_RS27330 (GTU79_27315) 5883890..5884324 + 435 WP_203520361.1 transposase -
GTU79_RS27335 (GTU79_27320) 5884321..5884671 + 351 WP_214513545.1 IS66 family insertion sequence element accessory protein TnpB -
GTU79_RS27340 (GTU79_27325) 5884702..5886294 + 1593 Protein_5413 IS66 family transposase -
GTU79_RS27345 (GTU79_27330) 5887041..5887421 - 381 WP_203520355.1 type II toxin-antitoxin system VapC family toxin Toxin
GTU79_RS27350 (GTU79_27335) 5887418..5887639 - 222 WP_214513546.1 CopG family transcriptional regulator Antitoxin
GTU79_RS27360 (GTU79_27345) 5888385..5888909 + 525 WP_214513547.1 PfkB family carbohydrate kinase -
GTU79_RS27365 (GTU79_27350) 5888936..5889346 + 411 WP_253073700.1 PfkB family carbohydrate kinase -
GTU79_RS27370 (GTU79_27355) 5889531..5890031 + 501 WP_214513548.1 hypothetical protein -
GTU79_RS27375 (GTU79_27360) 5890139..5890570 + 432 WP_214513549.1 pyruvate formate lyase family protein -
GTU79_RS27380 (GTU79_27365) 5890567..5891136 + 570 WP_214513550.1 pyruvate formate lyase family protein -
GTU79_RS27395 (GTU79_27380) 5891726..5892526 + 801 WP_253073444.1 pyruvate formate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14211.57 Da        Isoelectric Point: 6.4698

>T203323 WP_203520355.1 NZ_CP075169:c5887421-5887041 [Sodalis ligni]
MIAQLALFDTNILIDYLNGIAQAKDTLEKFSHKPAISVITWMEVMVGAKKMSPEQETQTRQFLAQFLLLPVTDEVSERAV
IIRHESKIKLPDAIIWATAQVNSRTLISRNPKDFGPESGVIMPYQL

Download         Length: 381 bp

>T203323 NZ_CP099912:c2017232-2017038 [Escherichia albertii]
ATGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCTGTTACGGTGAAAGCAATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CTACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8407.47 Da        Isoelectric Point: 4.7672

>AT203323 WP_214513546.1 NZ_CP075169:c5887639-5887418 [Sodalis ligni]
MIRIVIDLPDEDLRQLDNLKAIRHVARAEIIRQALAGYLENNRADGSSNAFGLWGNKKVDGVVYENQIREEWE

Download         Length: 222 bp

>AT203323 NZ_CP099912:2016861-2017039 [Escherichia albertii]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTT
CAATAGTGGCAGTTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References