Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 5285578..5286104 Replicon chromosome
Accession NZ_CP075169
Organism Sodalis ligni strain dw23

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag GTU79_RS24755 Protein ID WP_203523041.1
Coordinates 5285799..5286104 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag GTU79_RS24750 Protein ID WP_203521073.1
Coordinates 5285578..5285796 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU79_RS24710 (GTU79_24695) 5280601..5280894 - 294 WP_203521080.1 DUF1778 domain-containing protein -
GTU79_RS24715 (GTU79_24700) 5281339..5281587 + 249 WP_203521079.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTU79_RS24720 (GTU79_24705) 5281588..5281883 + 296 Protein_4884 type II toxin-antitoxin system RelE/ParE family toxin -
GTU79_RS24725 (GTU79_24710) 5282166..5282552 - 387 WP_214513463.1 type II toxin-antitoxin system VapC family toxin -
GTU79_RS24730 (GTU79_24715) 5282549..5282782 - 234 WP_203521076.1 prevent-host-death protein -
GTU79_RS24735 (GTU79_24720) 5282930..5283151 - 222 WP_203521075.1 helix-turn-helix transcriptional regulator -
GTU79_RS24740 (GTU79_24725) 5283148..5283291 - 144 WP_214514204.1 hypothetical protein -
GTU79_RS24745 (GTU79_24730) 5283523..5284917 - 1395 WP_203521074.1 group II intron reverse transcriptase/maturase -
GTU79_RS24750 (GTU79_24735) 5285578..5285796 + 219 WP_203521073.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
GTU79_RS24755 (GTU79_24740) 5285799..5286104 + 306 WP_203523041.1 type II toxin-antitoxin system toxin CcdB Toxin
GTU79_RS24760 (GTU79_24745) 5286203..5287267 - 1065 WP_203521072.1 mechanosensitive ion channel -
GTU79_RS24765 (GTU79_24750) 5287813..5288337 - 525 WP_214513464.1 hypothetical protein -
GTU79_RS24770 (GTU79_24755) 5289422..5290171 - 750 WP_203521070.1 glucose 1-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11607.51 Da        Isoelectric Point: 6.4777

>T203322 WP_203523041.1 NZ_CP075169:5285799-5286104 [Sodalis ligni]
VQFTVYQYKRASHYKMFVDVQSDIVDTPGRRVVIPLIESHHLSEKVNKTLFPLIRIDGENYRLMTTELSSVSVEVIGEII
ADISHCADEIKIAIKLMFWGI

Download         Length: 306 bp

>T203322 NZ_CP099912:2015193-2015295 [Escherichia albertii]
GCAAGGCAACTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAACA
GGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8192.15 Da        Isoelectric Point: 5.8395

>AT203322 WP_203521073.1 NZ_CP075169:5285578-5285796 [Sodalis ligni]
MKHRISVTVDKDNYQVLNAAGVNISGLVNEVIGKEASRIKAEEWKKENREGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT203322 NZ_CP099912:c2015296-2015065 [Escherichia albertii]
TAAAAAAAGACCGAATACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTCAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAGT
AAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References