Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 5280098..5280894 Replicon chromosome
Accession NZ_CP075169
Organism Sodalis ligni strain dw23

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag GTU79_RS24705 Protein ID WP_203521081.1
Coordinates 5280098..5280604 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag GTU79_RS24710 Protein ID WP_203521080.1
Coordinates 5280601..5280894 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU79_RS24675 (GTU79_24660) 5275207..5275539 - 333 WP_214513459.1 hypothetical protein -
GTU79_RS24680 (GTU79_24665) 5275543..5276466 - 924 WP_214513460.1 hypothetical protein -
GTU79_RS24685 (GTU79_24670) 5276463..5276867 - 405 WP_214513461.1 hypothetical protein -
GTU79_RS24690 (GTU79_24675) 5277238..5277636 - 399 WP_214513462.1 hypothetical protein -
GTU79_RS24695 (GTU79_24680) 5277910..5278095 - 186 WP_253073418.1 AAA family ATPase -
GTU79_RS24705 (GTU79_24690) 5280098..5280604 - 507 WP_203521081.1 GNAT family N-acetyltransferase Toxin
GTU79_RS24710 (GTU79_24695) 5280601..5280894 - 294 WP_203521080.1 DUF1778 domain-containing protein Antitoxin
GTU79_RS24715 (GTU79_24700) 5281339..5281587 + 249 WP_203521079.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTU79_RS24720 (GTU79_24705) 5281588..5281883 + 296 Protein_4884 type II toxin-antitoxin system RelE/ParE family toxin -
GTU79_RS24725 (GTU79_24710) 5282166..5282552 - 387 WP_214513463.1 type II toxin-antitoxin system VapC family toxin -
GTU79_RS24730 (GTU79_24715) 5282549..5282782 - 234 WP_203521076.1 prevent-host-death protein -
GTU79_RS24735 (GTU79_24720) 5282930..5283151 - 222 WP_203521075.1 helix-turn-helix transcriptional regulator -
GTU79_RS24740 (GTU79_24725) 5283148..5283291 - 144 WP_214514204.1 hypothetical protein -
GTU79_RS24745 (GTU79_24730) 5283523..5284917 - 1395 WP_203521074.1 group II intron reverse transcriptase/maturase -
GTU79_RS24750 (GTU79_24735) 5285578..5285796 + 219 WP_203521073.1 type II toxin-antitoxin system antitoxin CcdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5210473..5281148 70675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(76-142)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18343.45 Da        Isoelectric Point: 7.6706

>T203321 WP_203521081.1 NZ_CP075169:c5280604-5280098 [Sodalis ligni]
VILAPEPLHAGHILSSVCCGVDSMDNWLRQRAMKNQLTGASRTFVCCEDSKVKAYYSLASSAVMTTAAPGRFRCNMPDPI
PVVVLGRLAVNKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFELSPIDPMMLMVTLRDLVA
SVWQDESM

Download         Length: 507 bp

>T203321 NZ_CP099912:1848177-1848332 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGACCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10835.47 Da        Isoelectric Point: 9.7646

>AT203321 WP_203521080.1 NZ_CP075169:c5280894-5280601 [Sodalis ligni]
MPATNGVSVKRETLNLRIKPAERDLIDRAAKAKGKNRTDFVLEAAHAAAEEALIEQRIIMADPEAYQEFLVRLDQAPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT203321 NZ_CP099912:c1848165-1848107 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References