Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 5266765..5267291 Replicon chromosome
Accession NZ_CP075169
Organism Sodalis ligni strain dw23

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag GTU79_RS24620 Protein ID WP_203521098.1
Coordinates 5266986..5267291 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag GTU79_RS24615 Protein ID WP_113867773.1
Coordinates 5266765..5266983 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU79_RS24595 (GTU79_24580) 5262442..5262672 + 231 WP_214513455.1 hypothetical protein -
GTU79_RS30825 5262811..5262984 + 174 WP_247595566.1 hypothetical protein -
GTU79_RS24605 (GTU79_24590) 5264021..5265894 + 1874 Protein_4864 type IV secretory system conjugative DNA transfer family protein -
GTU79_RS24610 (GTU79_24595) 5265903..5266649 + 747 WP_203521099.1 MobC family replication-relaxation protein -
GTU79_RS24615 (GTU79_24600) 5266765..5266983 + 219 WP_113867773.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
GTU79_RS24620 (GTU79_24605) 5266986..5267291 + 306 WP_203521098.1 type II toxin-antitoxin system toxin CcdB Toxin
GTU79_RS24625 (GTU79_24610) 5267420..5268364 - 945 WP_203521097.1 zincin-like metallopeptidase domain-containing protein -
GTU79_RS24630 (GTU79_24615) 5268646..5269626 + 981 WP_203521096.1 transposase -
GTU79_RS24635 (GTU79_24620) 5269786..5269998 - 213 WP_253073693.1 hypothetical protein -
GTU79_RS24640 (GTU79_24625) 5270063..5270338 - 276 WP_214513456.1 hypothetical protein -
GTU79_RS31040 5270301..5270429 - 129 WP_275956943.1 hypothetical protein -
GTU79_RS24645 (GTU79_24630) 5271083..5272262 - 1180 Protein_4873 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5210473..5281148 70675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11688.49 Da        Isoelectric Point: 5.5433

>T203320 WP_203521098.1 NZ_CP075169:5266986-5267291 [Sodalis ligni]
MQFTVYQYKRASHYKMFVDVQSDIVDTPGRRMVIPLIESHHLSEKVNKTLFPLIRIDDENYRLMTTELSSVSVEVIGEII
ADVSHCADEIKNAINLMFWGV

Download         Length: 306 bp

>T203320 NZ_CP099912:1037310-1037462 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTGTACAGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8228.19 Da        Isoelectric Point: 6.4673

>AT203320 WP_113867773.1 NZ_CP075169:5266765-5266983 [Sodalis ligni]
MKHRVSVTVDKDNYQVLNAAGVNISGLVNEVIGKEARRIKAEEWKKENHEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT203320 NZ_CP099912:c1037268-1037216 [Escherichia albertii]
TTAGGTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References