Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4536951..4537584 Replicon chromosome
Accession NZ_CP075169
Organism Sodalis ligni strain dw23

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GTU79_RS21265 Protein ID WP_203524650.1
Coordinates 4537411..4537584 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GTU79_RS21260 Protein ID WP_203524649.1
Coordinates 4536951..4537358 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU79_RS21215 (GTU79_21200) 4532910..4533158 - 249 WP_203524642.1 hypothetical protein -
GTU79_RS21220 (GTU79_21205) 4533173..4533487 - 315 WP_203524643.1 hypothetical protein -
GTU79_RS21225 (GTU79_21210) 4533498..4534082 - 585 WP_203524644.1 Ig-like domain-containing protein -
GTU79_RS21230 (GTU79_21215) 4534079..4534288 - 210 WP_203524645.1 hypothetical protein -
GTU79_RS21235 (GTU79_21220) 4534300..4534577 - 278 Protein_4207 hypothetical protein -
GTU79_RS21240 (GTU79_21225) 4534688..4535104 - 417 WP_203524647.1 hypothetical protein -
GTU79_RS21245 (GTU79_21230) 4535101..4535595 - 495 WP_275956903.1 lysozyme -
GTU79_RS21250 (GTU79_21235) 4535595..4535837 - 243 WP_203524648.1 phage holin -
GTU79_RS30710 4536310..4536840 - 531 WP_253073389.1 hypothetical protein -
GTU79_RS21260 (GTU79_21245) 4536951..4537358 - 408 WP_203524649.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GTU79_RS21265 (GTU79_21250) 4537411..4537584 - 174 WP_203524650.1 type II toxin-antitoxin system HicA family toxin Toxin
GTU79_RS21270 (GTU79_21255) 4537726..4538166 - 441 WP_203524651.1 antiterminator Q family protein -
GTU79_RS21275 (GTU79_21260) 4538175..4539185 - 1011 WP_203524652.1 DUF968 domain-containing protein -
GTU79_RS21280 (GTU79_21265) 4539182..4539862 - 681 WP_203524653.1 DNA-binding protein -
GTU79_RS21285 (GTU79_21270) 4539855..4540244 - 390 WP_203524654.1 RusA family crossover junction endodeoxyribonuclease -
GTU79_RS21290 (GTU79_21275) 4540241..4542196 - 1956 WP_203524655.1 DNA cytosine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4500910..4555062 54152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-131)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6795.88 Da        Isoelectric Point: 11.0467

>T203318 WP_203524650.1 NZ_CP075169:c4537584-4537411 [Sodalis ligni]
VKQREFRRWLESQGVEVSDGTNHLKLRYKDRRSVMPRHPGDEIKEPLRKAIIKQLGL

Download         Length: 174 bp

>T203318 NZ_CP099912:189779-190081 [Escherichia albertii]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAGGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14769.90 Da        Isoelectric Point: 4.5502

>AT203318 WP_203524649.1 NZ_CP075169:c4537358-4536951 [Sodalis ligni]
MRYPVTLQPDTGGFVVSFPDIPEALTQGDSREEALAMALDALVTAFDFYFEDNRPVPAPSAITGDYVDVPLSVASKVMLL
NAFIESGLSQVELAARMGVKKQEVTRLFDLHHSTKIDTIQRAMSALGRRLELQAA

Download         Length: 408 bp

>AT203318 NZ_CP099912:190153-190491 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References