Detailed information of TA system TA203316

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 3657190..3658091
• Replicon: chromosome
• Accession: NZ_CP075169
• Organism: Sodalis ligni strain dw23

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: -
• Locus tag: GTU79_RS17035
• Protein ID: WP_203523185.1
• Coordinates: 3657190..3657723 (-)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: -
• Locus tag: GTU79_RS17040
• Protein ID: WP_203523186.1
• Coordinates: 3657720..3658091 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTU79_RS30530	3652826..3653947	+	1122	WP_253073326.1	tetratricopeptide repeat protein	-
GTU79_RS30535	3655676..3656092	-	417	WP_253073327.1	hypothetical protein	-
GTU79_RS30540	3656098..3656331	-	234	WP_253073328.1	hypothetical protein	-
GTU79_RS30545	3656328..3656666	-	339	WP_253073329.1	DUF262 domain-containing protein	-
GTU79_RS17035 (GTU79_17025)	3657190..3657723	-	534	WP_203523185.1	RES family NAD+ phosphorylase	Toxin
GTU79_RS17040 (GTU79_17030)	3657720..3658091	-	372	WP_203523186.1	DUF2384 domain-containing protein	Antitoxin
GTU79_RS17045 (GTU79_17035)	3658531..3658812	+	282	WP_203523187.1	Arm DNA-binding domain-containing protein	-
GTU79_RS17050 (GTU79_17040)	3658879..3659430	-	552	WP_203523188.1	TetR/AcrR family transcriptional regulator	-
GTU79_RS17055 (GTU79_17045)	3659513..3660553	+	1041	WP_203523189.1	aldo/keto reductase	-
GTU79_RS17060 (GTU79_17050)	3660821..3661912	-	1092	WP_253073330.1	bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada	-
GTU79_RS17065 (GTU79_17055)	3662109..3662660	-	552	WP_203523191.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
GTU79_RS17070 (GTU79_17060)	3662726..3662920	-	195	WP_253073331.1	alpha-ketoglutarate-dependent dioxygenase AlkB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (14-150)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 19494.07 Da
• Isoelectric Point: 4.5688

>T203316 WP_203523185.1 NZ_CP075169:c3657723-3657190 [Sodalis ligni]
MIDVILDGGRFPAFYRIIVPAFASTPLSGMGAARQGGRFNRPRQEALYLSADEVTALAEYKQDNPWLQPGTICTFFAKDL
RVADLSAGFDPKHWGDLWADFAVDWRTERFGNGVEPPSWYMADDVVAAGLDGILFPSQARPGGTNLVIYRSSQLTDSQLC
VYDPSGNLKSILPNTLM

Nucleotide

• Length: 534 bp

>T203316 NZ_CP099911:80728-81144 [Escherichia albertii]
GTGAACAAGATCTATATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCACGTTCAGCTGGTTGACGCATTCTGTGAGCGACTCGATGCCGTCCTGCCCTGGGATCGCGCC
GCGGTGGATGCGACCACAGAGATTAAGGTGGCGCTGCGCCTCGCCGGAACGCCGATAGGCCCGAACGACACGGCGATTTC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTTCCGGGCCTGATACTGG
AAGACTGGGCCGGTTAG

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13473.21 Da
• Isoelectric Point: 6.4656

>AT203316 WP_203523186.1 NZ_CP075169:c3658091-3657720 [Sodalis ligni]
MSASLPNPLSVQFREPNTAYLSPARVGDFFGFRIQELAERAHVHRNTPSSRPQAQQLQQYLVDLVRVLAVATEMTGDAQQ
AVFLIRNEPLRAFGYKTADALLRDGRADDVIAYLESLAGGAAG

Nucleotide

• Length: 372 bp

>AT203316 NZ_CP099911:80501-80731 [Escherichia albertii]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGTGCCATCCGTCTGCCCCGGGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGGCAGCATCATCCTGCGTCCCGTCCGACCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTATCAGCGACGAAGGACGATTTAACCTGTGA