Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3635025..3635551 Replicon chromosome
Accession NZ_CP075169
Organism Sodalis ligni strain dw23

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag GTU79_RS16955 Protein ID WP_214513176.1
Coordinates 3635246..3635551 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag GTU79_RS16950 Protein ID WP_214513175.1
Coordinates 3635025..3635243 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU79_RS30500 3630584..3630796 + 213 WP_253073669.1 cag pathogenicity island Cag12 family protein -
GTU79_RS16930 (GTU79_16920) 3630874..3631172 + 299 Protein_3344 TrbM/KikA/MpfK family conjugal transfer protein -
GTU79_RS16935 (GTU79_16925) 3631194..3631445 + 252 WP_214514163.1 hypothetical protein -
GTU79_RS16940 (GTU79_16930) 3632290..3634155 + 1866 Protein_3346 type IV secretion system DNA-binding domain-containing protein -
GTU79_RS16945 (GTU79_16935) 3634164..3634909 + 746 Protein_3347 MobC family replication-relaxation protein -
GTU79_RS16950 (GTU79_16940) 3635025..3635243 + 219 WP_214513175.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
GTU79_RS16955 (GTU79_16945) 3635246..3635551 + 306 WP_214513176.1 type II toxin-antitoxin system toxin CcdB Toxin
GTU79_RS16960 (GTU79_16950) 3635682..3636625 - 944 Protein_3350 zincin-like metallopeptidase domain-containing protein -
GTU79_RS16970 (GTU79_16960) 3638745..3639923 + 1179 WP_214513178.1 IS21 family transposase -
GTU79_RS16975 (GTU79_16965) 3639923..3640484 + 562 Protein_3352 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3595716..3654147 58431


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11571.43 Da        Isoelectric Point: 6.8684

>T203315 WP_214513176.1 NZ_CP075169:3635246-3635551 [Sodalis ligni]
MQFTVYQYKRASHYKMFVDVQSDIVDTPGRRMVIPLIASHHLSEKVNKTLFPLIRIDGENYRLMTTELSSVSVEVIGEII
ADVSHCANEIKNAINLMFWGV

Download         Length: 306 bp

>T203315 NZ_CP099910:c4339174-4338797 [Escherichia albertii]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCTGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8256.20 Da        Isoelectric Point: 6.4674

>AT203315 WP_214513175.1 NZ_CP075169:3635025-3635243 [Sodalis ligni]
MKHRVSVTVDKDNYQVLNAAGVNISGLVNEVIGREARRIKAEEWKKENHEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT203315 NZ_CP099910:c4339632-4339264 [Escherichia albertii]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCACCATCAGCATACCGTGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References