Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2516195..2516973 Replicon chromosome
Accession NZ_CP075169
Organism Sodalis ligni strain dw23

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag GTU79_RS11725 Protein ID WP_203521793.1
Coordinates 2516485..2516973 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag GTU79_RS11720 Protein ID WP_203521794.1
Coordinates 2516195..2516488 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU79_RS30265 2513158..2513700 - 543 Protein_2304 DDE-type integrase/transposase/recombinase -
GTU79_RS11705 (GTU79_11700) 2513892..2514578 + 687 WP_214513957.1 IS110 family transposase -
GTU79_RS11715 (GTU79_11710) 2514980..2515779 - 800 Protein_2306 site-specific integrase -
GTU79_RS11720 (GTU79_11715) 2516195..2516488 + 294 WP_203521794.1 DUF1778 domain-containing protein Antitoxin
GTU79_RS11725 (GTU79_11720) 2516485..2516973 + 489 WP_203521793.1 GNAT family N-acetyltransferase Toxin
GTU79_RS11730 (GTU79_11725) 2517037..2517945 - 909 Protein_2309 integrase arm-type DNA-binding domain-containing protein -
GTU79_RS11740 (GTU79_11735) 2518367..2519729 - 1363 Protein_2310 anaerobic C4-dicarboxylate transporter -
GTU79_RS11745 (GTU79_11740) 2519961..2520422 - 462 WP_214513958.1 hypothetical protein -
GTU79_RS11750 (GTU79_11745) 2521052..2521522 + 471 WP_132922004.1 MarR family transcriptional regulator -
GTU79_RS30990 2521519..2521653 + 135 WP_275956929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2513155..2513691 536


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17553.56 Da        Isoelectric Point: 7.2655

>T203306 WP_203521793.1 NZ_CP075169:2516485-2516973 [Sodalis ligni]
VILAPEPLHVGHILSSFCCGVDSMDNWLKQRAMKNQLTGASRTFVCCDDLKVMAYYSLASSAVMTTAAPGRFRRNMPDPI
PVVVLGRLAVDTSLHGQGVGRALVRDAGLRVIQVAETIGIRGVLVHALSTEAREFYLRVGFEPSPIDPMMLMVTLGDLVE
SV

Download         Length: 489 bp

>T203306 NZ_CP099910:2425795-2426082 [Escherichia albertii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10834.48 Da        Isoelectric Point: 10.1425

>AT203306 WP_203521794.1 NZ_CP075169:2516195-2516488 [Sodalis ligni]
MPATNGVSVKRQTLNLRIKPAERDLIDRAAKAKGKNRTDFVLEAAHAAAEDVLIEQRIIMADPDAYQEFLVRLDQAPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT203306 NZ_CP099910:2425556-2425795 [Escherichia albertii]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References