Detailed information of TA system TA203303

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1480827..1481435
• Replicon: chromosome
• Accession: NZ_CP075169
• Organism: Sodalis ligni strain dw23

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: -
• Locus tag: GTU79_RS06905
• Protein ID: WP_214513796.1
• Coordinates: 1480827..1481009 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: GTU79_RS06910
• Protein ID: WP_132922917.1
• Coordinates: 1481076..1481435 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTU79_RS06875 (GTU79_06875)	1475837..1476175	+	339	WP_009639071.1	P-II family nitrogen regulator	-
GTU79_RS06880 (GTU79_06880)	1476213..1477499	+	1287	WP_165934155.1	ammonium transporter AmtB	-
GTU79_RS06885 (GTU79_06885)	1477893..1478762	-	870	WP_203522392.1	acyl-CoA thioesterase II	-
GTU79_RS06890 (GTU79_06890)	1479013..1479579	+	567	WP_132922920.1	YbaY family lipoprotein	-
GTU79_RS06895 (GTU79_06895)	1479644..1479958	-	315	WP_203522391.1	MGMT family protein	-
GTU79_RS06905 (GTU79_06905)	1480827..1481009	-	183	WP_214513796.1	hemolysin expression modulator Hha	Toxin
GTU79_RS06910 (GTU79_06910)	1481076..1481435	-	360	WP_132922917.1	Hha toxicity modulator TomB	Antitoxin
GTU79_RS06915 (GTU79_06915)	1482078..1482218	-	141	WP_132922916.1	type B 50S ribosomal protein L36	-
GTU79_RS06920 (GTU79_06920)	1482206..1482493	-	288	WP_214513797.1	type B 50S ribosomal protein L31	-
GTU79_RS06925 (GTU79_06925)	1482876..1486016	-	3141	WP_203522389.1	efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	acrB / acrA	1480827..1489128	8301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (1-57)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7259.39 Da
• Isoelectric Point: 6.9779

>T203303 WP_214513796.1 NZ_CP075169:c1481009-1480827 [Sodalis ligni]
MRLRKCRTLETLERVIEKNKYELSDDELEIFNSAADHRLAELTMDKLYDKVPVSVWKYVR

Nucleotide

• Length: 183 bp

>T203303 NZ_CP099910:1054045-1054197 [Escherichia albertii]
ATGCTAACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13634.14 Da
• Isoelectric Point: 4.5349

>AT203303 WP_132922917.1 NZ_CP075169:c1481435-1481076 [Sodalis ligni]
MDEYSPKRHDIAQLKFLCATLYDEGIASLGDSYHGWVNDPASAINLQMNELIDHIASYMVSFKLKYHNESDLTDHVESFL
DDTFTLFSSSGINNLDVQRWRTSRSRLFGTFSETELCIS

Nucleotide

• Length: 360 bp

>AT203303 NZ_CP099910:c1054003-1053951 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT