Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 992507..993141 Replicon chromosome
Accession NZ_CP075169
Organism Sodalis ligni strain dw23

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GTU79_RS04635 Protein ID WP_203522728.1
Coordinates 992507..992782 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GTU79_RS04640 Protein ID WP_203522727.1
Coordinates 992779..993141 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU79_RS04615 (GTU79_04615) 989307..989459 - 153 WP_214513723.1 hypothetical protein -
GTU79_RS04620 (GTU79_04620) 990059..990376 - 318 WP_132923316.1 multidrug efflux SMR transporter -
GTU79_RS04625 (GTU79_04625) 990554..991495 + 942 WP_203522729.1 nucleoside hydrolase -
GTU79_RS04630 (GTU79_04630) 991508..992344 - 837 WP_203523153.1 helix-turn-helix transcriptional regulator -
GTU79_RS04635 (GTU79_04635) 992507..992782 + 276 WP_203522728.1 type II toxin-antitoxin system HicA family toxin Toxin
GTU79_RS04640 (GTU79_04640) 992779..993141 + 363 WP_203522727.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GTU79_RS04645 (GTU79_04645) 993307..993702 + 396 Protein_907 phosphate-starvation-inducible protein PsiE -
GTU79_RS04650 (GTU79_04650) 993833..994399 + 567 WP_203522726.1 TIGR00730 family Rossman fold protein -
GTU79_RS04655 (GTU79_04655) 994677..995489 + 813 WP_203522725.1 MipA/OmpV family protein -
GTU79_RS04660 (GTU79_04660) 995500..996177 + 678 WP_132923309.1 response regulator transcription factor -
GTU79_RS04665 (GTU79_04665) 996235..997590 + 1356 WP_203522724.1 HAMP domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-87)

Antitoxin

Uncharacterised protein family HicB

(61-113)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10073.73 Da        Isoelectric Point: 10.6504

>T203302 WP_203522728.1 NZ_CP075169:992507-992782 [Sodalis ligni]
MRQKITGLRKKQRTVLNQIFKTPVPSGVKWSDIESLVCALGGEIKEGSGSRVRLLLNGCIARFHRPHPSPEADKGALANL
REWLESIGVEP

Download         Length: 276 bp

>T203302 NZ_CP099910:889818-890222 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13537.42 Da        Isoelectric Point: 5.2306

>AT203302 WP_203522727.1 NZ_CP075169:992779-993141 [Sodalis ligni]
MKKVLKTPNTMVVAGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSIDGLKSEGEVSLREYLEDCRENHIDPYEREEKVK
TFTLRYPESFGEQLAVAAAEHHVSVNSFIVETLNERLKHA

Download         Length: 363 bp

>AT203302 NZ_CP099910:889571-889837 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGTCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References