Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 315717..316208 Replicon chromosome
Accession NZ_CP075169
Organism Sodalis ligni strain dw23

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GTU79_RS01435 Protein ID WP_253073470.1
Coordinates 315717..315965 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GTU79_RS01440 Protein ID WP_203524537.1
Coordinates 315993..316208 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU79_RS01395 (GTU79_01395) 311298..311492 - 195 WP_214513648.1 hypothetical protein -
GTU79_RS01400 (GTU79_01400) 311626..312647 + 1022 Protein_269 IS21 family transposase -
GTU79_RS01405 (GTU79_01405) 312644..313432 + 789 WP_214513649.1 IS21-like element helper ATPase IstB -
GTU79_RS01410 (GTU79_01410) 313772..314071 - 300 WP_203524389.1 helix-turn-helix transcriptional regulator -
GTU79_RS01415 (GTU79_01415) 314075..314424 - 350 Protein_272 type II toxin-antitoxin system RelE/ParE family toxin -
GTU79_RS01420 (GTU79_01420) 314540..314734 - 195 WP_203524388.1 helix-turn-helix transcriptional regulator -
GTU79_RS01430 (GTU79_01430) 315132..315605 + 474 WP_203524387.1 hypothetical protein -
GTU79_RS01435 (GTU79_01435) 315717..315965 - 249 WP_253073470.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTU79_RS01440 (GTU79_01440) 315993..316208 - 216 WP_203524537.1 stability determinant Antitoxin
GTU79_RS01445 (GTU79_01445) 316450..316842 - 393 WP_203524386.1 hypothetical protein -
GTU79_RS01450 (GTU79_01450) 316878..318061 - 1184 Protein_278 IS3 family transposase -
GTU79_RS01455 (GTU79_01455) 318512..318811 - 300 WP_203524385.1 XRE family transcriptional regulator -
GTU79_RS01460 (GTU79_01460) 318991..321021 + 2031 WP_203524384.1 DNA helicase Rep -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 306568..330981 24413
- inside IScluster/Tn - - 312644..318088 5444


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(20-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9296.75 Da        Isoelectric Point: 5.4797

>T203299 WP_253073470.1 NZ_CP075169:c315965-315717 [Sodalis ligni]
MQEPTCITLSPSSLSTIIPAESLLQHIEESVIPATEHPYLYRPGRVPGTREIVVIPHYIVVYRVLSDYLEVLAVLHARQE
YP

Download         Length: 249 bp

>T203299 NZ_CP099909:76729-77109 [Escherichia albertii]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8130.37 Da        Isoelectric Point: 11.0560

>AT203299 WP_203524537.1 NZ_CP075169:c316208-315993 [Sodalis ligni]
IAGLAWKRFVKKQSPIVSEFETQEQAGRYECWFRAKVNTSMNAAIPNVPHNEVMAGARKVIEKSNNRRRLA

Download         Length: 216 bp

>AT203299 NZ_CP099909:76508-76729 [Escherichia albertii]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References