Detailed information of TA system TA203297

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1303309..1304087
• Replicon: chromosome
• Accession: NZ_CP075146
• Organism: Xanthomonas campestris pv. campestris strain GBBC1458

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: Q8P667
• Locus tag: KIV67_RS05500
• Protein ID: WP_011038220.1
• Coordinates: 1303309..1303800 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: Q8P668
• Locus tag: KIV67_RS05505
• Protein ID: WP_011038219.1
• Coordinates: 1303797..1304087 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KIV67_RS05485 (KIV67_05480)	1299637..1300512	+	876	WP_011038222.1	30S ribosomal protein S6--L-glutamate ligase	-
KIV67_RS05490 (KIV67_05485)	1301162..1301839	+	678	WP_003490678.1	response regulator transcription factor	-
KIV67_RS05495 (KIV67_05490)	1301832..1303166	+	1335	WP_019237347.1	HAMP domain-containing sensor histidine kinase	-
KIV67_RS05500 (KIV67_05495)	1303309..1303800	-	492	WP_011038220.1	GNAT family N-acetyltransferase	Toxin
KIV67_RS05505 (KIV67_05500)	1303797..1304087	-	291	WP_011038219.1	DUF1778 domain-containing protein	Antitoxin
KIV67_RS05510 (KIV67_05505)	1304162..1304563	-	402	WP_019237348.1	SymE family type I addiction module toxin	-
KIV67_RS05515 (KIV67_05510)	1305095..1305718	-	624	WP_011038217.1	dephospho-CoA kinase	-
KIV67_RS05520 (KIV67_05515)	1305732..1306595	-	864	WP_011038216.1	A24 family peptidase	-
KIV67_RS05525 (KIV67_05520)	1306602..1307858	-	1257	WP_011038215.1	type II secretion system F family protein	-
KIV67_RS05530 (KIV67_05525)	1308185..1308625	+	441	WP_011038214.1	pilin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (42-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17638.31 Da
• Isoelectric Point: 8.1192

>T203297 WP_011038220.1 NZ_CP075146:c1303800-1303309 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Nucleotide

• Length: 492 bp

>T203297 NZ_CP099907:c4341745-4341368 [Escherichia albertii]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCTGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10678.23 Da
• Isoelectric Point: 10.5480

>AT203297 WP_011038219.1 NZ_CP075146:c1304087-1303797 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLITASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Nucleotide

• Length: 291 bp

>AT203297 NZ_CP099907:c4342203-4341835 [Escherichia albertii]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCACCATCAGCATACCGTGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: Q8P667

Antitoxin

• AlphaFold DB: Q8P668