Detailed information of TA system TA203296

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 24317..24942
• Replicon: plasmid pCFSAN033950
• Accession: NZ_CP075142
• Organism: Salmonella enterica strain CFSAN033950

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A760NIL6
• Locus tag: ACV97_RS23770
• Protein ID: WP_064239975.1
• Coordinates: 24317..24715 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ACV97_RS23775
• Protein ID: WP_064239974.1
• Coordinates: 24715..24942 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACV97_RS23755 (ACV97_23755)	20523..21017	+	495	WP_077951228.1	entry exclusion protein	-
ACV97_RS23760 (ACV97_23760)	21053..21784	+	732	WP_058215169.1	conjugal transfer complement resistance protein TraT	-
ACV97_RS23765 (ACV97_23765)	22161..24308	+	2148	WP_064239976.1	type IV conjugative transfer system coupling protein TraD	-
ACV97_RS23770 (ACV97_23770)	24317..24715	-	399	WP_064239975.1	tRNA(fMet)-specific endonuclease VapC	Toxin
ACV97_RS23775 (ACV97_23775)	24715..24942	-	228	WP_064239974.1	toxin-antitoxin system antitoxin VapB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	rck / rck / pefD / pefC / pefA / pefB	1..75400	75400

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14928.18 Da
• Isoelectric Point: 8.5264

>T203296 WP_064239975.1 NZ_CP075142:c24715-24317 [Salmonella enterica]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSITLMELIYGAEKSQMPERNLAVIEGFVSRLDVLDYDTPAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVGGLRTEDWN

Nucleotide

• Length: 399 bp

>T203296 NZ_CP099907:c4143417-4143076 [Escherichia albertii]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCGCCCGTCGTGGTCTGGCAAACATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGACTGAACCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTTGATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTGCGGGCGAGGCAGGCTACAGGTCAGCTGCGTCGCTG
CCATAACACCACGGCACGGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8564.59 Da
• Isoelectric Point: 4.7513

>AT203296 WP_064239974.1 NZ_CP075142:c24942-24715 [Salmonella enterica]
METSVFLSNRSQAVRLPKAVALPEHVKRVEVIAVGRTRIITPAGESWDEWFDGNNVSADFMDNREQPSMQERESF

Nucleotide

• Length: 228 bp

>AT203296 NZ_CP099907:c4143783-4143448 [Escherichia albertii]
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTTACACCACGCTTCACTGCACGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGCTGATGAAACAACTGGAGCTGAAACTGGCTGACGGTGAACTCTCCCCCTGCCAACAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA

Structures

Toxin

• AlphaFold DB: A0A760NIL6