Detailed information of TA system TA203292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 4113710..4114286
• Replicon: chromosome
• Accession: NZ_CP075141
• Organism: Salmonella enterica strain CFSAN033950

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: M7RG88
• Locus tag: ACV97_RS20185
• Protein ID: WP_001131963.1
• Coordinates: 4113999..4114286 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: B5R9R5
• Locus tag: ACV97_RS20180
• Protein ID: WP_000063142.1
• Coordinates: 4113710..4114012 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACV97_RS20165 (4110220)	4110220..4112370	+	2151	WP_000379927.1	pyruvate/proton symporter BtsT	-
ACV97_RS20170 (4112465)	4112465..4112668	+	204	WP_000460616.1	YbdD/YjiX family protein	-
ACV97_RS20175 (4112679)	4112679..4113635	+	957	WP_000187839.1	GTPase	-
ACV97_RS20180 (4113710)	4113710..4114012	-	303	WP_000063142.1	BrnA antitoxin family protein	Antitoxin
ACV97_RS20185 (4113999)	4113999..4114286	-	288	WP_001131963.1	BrnT family toxin	Toxin
ACV97_RS20190 (4114555)	4114555..4115469	-	915	WP_000290512.1	restriction endonuclease	-
ACV97_RS20195 (4115667)	4115667..4119176	+	3510	WP_001043484.1	type I restriction-modification system endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (37-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11294.80 Da
• Isoelectric Point: 9.5894

>T203292 WP_001131963.1 NZ_CP075141:c4114286-4113999 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Nucleotide

• Length: 288 bp

>T203292 NZ_CP099907:3545536-3545754 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGGCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11373.96 Da
• Isoelectric Point: 10.1293

>AT203292 WP_000063142.1 NZ_CP075141:c4114012-4113710 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Nucleotide

• Length: 303 bp

>AT203292 NZ_CP099907:3545136-3545510 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Structures

Toxin

• PDB: 7VD7

Antitoxin

• AlphaFold DB: A0A4D6PB01