Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3477802..3478422 | Replicon | chromosome |
Accession | NZ_CP075141 | ||
Organism | Salmonella enterica strain CFSAN033950 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | V1H8E6 |
Locus tag | ACV97_RS17060 | Protein ID | WP_001280991.1 |
Coordinates | 3478204..3478422 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | V1H4V6 |
Locus tag | ACV97_RS17055 | Protein ID | WP_000344807.1 |
Coordinates | 3477802..3478176 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ACV97_RS17045 (3472941) | 3472941..3474134 | + | 1194 | WP_001039202.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
ACV97_RS17050 (3474157) | 3474157..3477306 | + | 3150 | WP_001132508.1 | efflux RND transporter permease AcrB | - |
ACV97_RS17055 (3477802) | 3477802..3478176 | + | 375 | WP_000344807.1 | Hha toxicity modulator TomB | Antitoxin |
ACV97_RS17060 (3478204) | 3478204..3478422 | + | 219 | WP_001280991.1 | HHA domain-containing protein | Toxin |
ACV97_RS17065 (3478601) | 3478601..3479152 | + | 552 | WP_001278792.1 | maltose O-acetyltransferase | - |
ACV97_RS17070 (3479269) | 3479269..3479739 | + | 471 | WP_000136181.1 | YlaC family protein | - |
ACV97_RS17075 (3479795) | 3479795..3479935 | - | 141 | WP_001197749.1 | type B 50S ribosomal protein L36 | - |
ACV97_RS17080 (3479941) | 3479941..3480201 | - | 261 | WP_000801415.1 | type B 50S ribosomal protein L31 | - |
ACV97_RS17085 (3480426) | 3480426..3481976 | + | 1551 | WP_000213139.1 | EAL domain-containing protein | - |
ACV97_RS17095 (3482207) | 3482207..3482596 | + | 390 | WP_000961285.1 | MGMT family protein | - |
ACV97_RS17100 (3482629) | 3482629..3483198 | - | 570 | WP_000779803.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8613.97 Da Isoelectric Point: 8.9008
>T203291 WP_001280991.1 NZ_CP075141:3478204-3478422 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T203291 NZ_CP099907:c2864516-2864361 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAGTCGCCCTGATCGTCATCTGTTTAACCGTCATTGTTACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA
ATGAAGCAGCAAAAGGCGATGTTAGTCGCCCTGATCGTCATCTGTTTAACCGTCATTGTTACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14453.27 Da Isoelectric Point: 5.1444
>AT203291 WP_000344807.1 NZ_CP075141:3477802-3478176 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT203291 NZ_CP099907:2864528-2864586 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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