Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3477802..3478422 Replicon chromosome
Accession NZ_CP075141
Organism Salmonella enterica strain CFSAN033950

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag ACV97_RS17060 Protein ID WP_001280991.1
Coordinates 3478204..3478422 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag ACV97_RS17055 Protein ID WP_000344807.1
Coordinates 3477802..3478176 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACV97_RS17045 (3472941) 3472941..3474134 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ACV97_RS17050 (3474157) 3474157..3477306 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
ACV97_RS17055 (3477802) 3477802..3478176 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
ACV97_RS17060 (3478204) 3478204..3478422 + 219 WP_001280991.1 HHA domain-containing protein Toxin
ACV97_RS17065 (3478601) 3478601..3479152 + 552 WP_001278792.1 maltose O-acetyltransferase -
ACV97_RS17070 (3479269) 3479269..3479739 + 471 WP_000136181.1 YlaC family protein -
ACV97_RS17075 (3479795) 3479795..3479935 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
ACV97_RS17080 (3479941) 3479941..3480201 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
ACV97_RS17085 (3480426) 3480426..3481976 + 1551 WP_000213139.1 EAL domain-containing protein -
ACV97_RS17095 (3482207) 3482207..3482596 + 390 WP_000961285.1 MGMT family protein -
ACV97_RS17100 (3482629) 3482629..3483198 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T203291 WP_001280991.1 NZ_CP075141:3478204-3478422 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T203291 NZ_CP099907:c2864516-2864361 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAGTCGCCCTGATCGTCATCTGTTTAACCGTCATTGTTACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT203291 WP_000344807.1 NZ_CP075141:3477802-3478176 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT203291 NZ_CP099907:2864528-2864586 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References