Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206567..207327 Replicon chromosome
Accession NZ_CP075141
Organism Salmonella enterica strain CFSAN033950

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag ACV97_RS00975 Protein ID WP_000533909.1
Coordinates 206842..207327 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag ACV97_RS00970 Protein ID WP_000965886.1
Coordinates 206567..206854 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACV97_RS00945 (201862) 201862..202164 + 303 WP_000605590.1 YsaB family lipoprotein -
ACV97_RS00950 (202303) 202303..203214 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
ACV97_RS00955 (203224) 203224..205293 + 2070 WP_064239719.1 glycine--tRNA ligase subunit beta -
ACV97_RS00960 (205475) 205475..205750 + 276 Protein_190 IS3 family transposase -
ACV97_RS00965 (205922) 205922..206389 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
ACV97_RS00970 (206567) 206567..206854 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
ACV97_RS00975 (206842) 206842..207327 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
ACV97_RS00980 (207699) 207699..208238 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
ACV97_RS00985 (208412) 208412..208624 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
ACV97_RS00990 (208913) 208913..209203 - 291 WP_000455790.1 HTH-type transcriptional regulator -
ACV97_RS00995 (209642) 209642..210352 + 711 WP_000190524.1 DUF3053 domain-containing protein -
ACV97_RS01000 (210402) 210402..211376 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
ACV97_RS01005 (211595) 211595..212257 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T203271 WP_000533909.1 NZ_CP075141:206842-207327 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T203271 NZ_CP099906:c2052424-2052272 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTTCACGGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT203271 WP_000965886.1 NZ_CP075141:206567-206854 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT203271 NZ_CP099906:2052469-2052517 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References