Detailed information of TA system TA203269

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4904324..4904940
• Replicon: chromosome
• Accession: NZ_CP075140
• Organism: Salmonella enterica strain CFSAN044865

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A8E9YCX3
• Locus tag: A7R87_RS23400
• Protein ID: WP_023249114.1
• Coordinates: 4904324..4904698 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8E9YHE9
• Locus tag: A7R87_RS23405
• Protein ID: WP_001523745.1
• Coordinates: 4904698..4904940 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7R87_RS23385 (4901826)	4901826..4902728	+	903	WP_070789960.1	formate dehydrogenase subunit beta	-
A7R87_RS23390 (4902725)	4902725..4903360	+	636	WP_000829028.1	formate dehydrogenase cytochrome b556 subunit	-
A7R87_RS23395 (4903357)	4903357..4904286	+	930	WP_023249115.1	formate dehydrogenase accessory protein FdhE	-
A7R87_RS23400 (4904324)	4904324..4904698	-	375	WP_023249114.1	type II toxin-antitoxin system VapC family toxin	Toxin
A7R87_RS23405 (4904698)	4904698..4904940	-	243	WP_001523745.1	CopG family transcriptional regulator	Antitoxin
A7R87_RS23410 (4905145)	4905145..4906071	+	927	Protein_4614	alpha/beta hydrolase	-
A7R87_RS23415 (4906157)	4906157..4906468	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
A7R87_RS23420 (4906465)	4906465..4906911	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
A7R87_RS23425 (4906926)	4906926..4907867	-	942	WP_024134888.1	fatty acid biosynthesis protein FabY	-
A7R87_RS23430 (4907912)	4907912..4908349	-	438	WP_023249111.1	D-aminoacyl-tRNA deacylase	-
A7R87_RS23435 (4908346)	4908346..4909218	-	873	WP_023249110.1	virulence factor BrkB family protein	-
A7R87_RS23440 (4909212)	4909212..4909811	-	600	WP_023249109.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-112)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-47)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13836.12 Da
• Isoelectric Point: 8.0689

>T203269 WP_023249114.1 NZ_CP075140:c4904698-4904324 [Salmonella enterica]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNVIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFAGIPGVITPYHL

Nucleotide

• Length: 375 bp

>T203269 NZ_CP099906:1952408-1952731 [Escherichia albertii]
ATTTTATCTGTACCGACCACGGTGCCAATTTCGTCACGCCTGTCGCCCGTACAGGTCTGGCAGCAACTGTTAACATACCT
GCTGGAGCATCATTACGGCCTCACACTCAACGACACGCCATTCCACGACGACGCGGCTATCGAAGAACATATCGAGGCGG
GAATAACACTTGCTGATGCGGTGAATTTCCTGGTCGAAAAGTACGAACTGGTTCGTATCGACCGAAAGGGATTTTCGTGG
CAAGAACAAACCCCGTATATTTCCGTAGTGGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAACGTGAA
ATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9437.77 Da
• Isoelectric Point: 4.4463

>AT203269 WP_001523745.1 NZ_CP075140:c4904940-4904698 [Salmonella enterica]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Nucleotide

• Length: 243 bp

>AT203269 NZ_CP099906:1952050-1952370 [Escherichia albertii]
ATGAAAAATTCATGGGGACTGAAGCGCGACATGACGCCGTGCTTCGGTGCAAGGCTTGTGCAGGAAGGCCGTCGTCTGCA
TTTTCTGGCGGACCGTGCAGATATTAGCGGTGCGTTTAATGAGGAGGAGGCGCTACGTCTGGATCAAGCATTTCCGCCAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTAAATCCACGCCATCAGCATTGCGTCACGTTGCATCATAAC
GGACTTACCTGCGAGGCGGATACTCTCGGCTCTCATGGCTACGTTTACATCGTTATTTATCCTCAGACATCGAGCCAGTA
A