Detailed information of TA system TA203268

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 4581175..4581932
• Replicon: chromosome
• Accession: NZ_CP075140
• Organism: Salmonella enterica strain CFSAN044865

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: A7R87_RS22070
• Protein ID: WP_023249556.1
• Coordinates: 4581450..4581932 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A5Y0S3F2
• Locus tag: A7R87_RS22065
• Protein ID: WP_001750501.1
• Coordinates: 4581175..4581459 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7R87_RS22050 (4577368)	4577368..4579056	-	1689	WP_070789718.1	PilN family type IVB pilus formation outer membrane protein	-
A7R87_RS22055 (4579077)	4579077..4579514	-	438	WP_023249558.1	type IV pilus biogenesis protein PilM	-
A7R87_RS22060 (4579514)	4579514..4580788	-	1275	WP_044136653.1	TcpQ domain-containing protein	-
A7R87_RS22065 (4581175)	4581175..4581459	+	285	WP_001750501.1	DUF1778 domain-containing protein	Antitoxin
A7R87_RS22070 (4581450)	4581450..4581932	+	483	WP_023249556.1	GNAT family N-acetyltransferase	Toxin
A7R87_RS22075 (4582211)	4582211..4582606	-	396	WP_023249555.1	glyoxalase/bleomycin resistance protein/dioxygenase	-
A7R87_RS22080 (4582873)	4582873..4583274	-	402	WP_023249554.1	HD domain-containing protein	-
A7R87_RS22085 (4583403)	4583403..4583570	-	168	WP_170245768.1	hypothetical protein	-
A7R87_RS22090 (4583495)	4583495..4584263	+	769	Protein_4362	IS3 family transposase	-
A7R87_RS22095 (4585299)	4585299..4586147	-	849	WP_024149777.1	SdiA-regulated domain-containing protein	-
A7R87_RS22100 (4586261)	4586261..4586518	-	258	WP_023249551.1	FaeA/PapI family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4584033..4584161	128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (30-149)

Antitoxin

• Vibrio phage ICP1, Orf50 (13-87)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17947.68 Da
• Isoelectric Point: 6.8355

>T203268 WP_023249556.1 NZ_CP075140:4581450-4581932 [Salmonella enterica]
MEINVTAPELLNEEHILQSFDCGNDVLSDWLCRRAMKNQHLNASRTFVICLECTKRVVGYYSIATGSISHVDLGRSLRQN
MPDPVPVVLLGRLAIDKCTQGQNFGKWLLNDAVTRVSNLADQVGIKAIMVHAIDEQAKAFYEYFGFVQSPVAPNTLFYKI

Nucleotide

• Length: 483 bp

>T203268 NZ_CP099906:c1047215-1047113 [Escherichia albertii]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAACA
GGAATCGTTTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11033.58 Da
• Isoelectric Point: 8.5171

>AT203268 WP_001750501.1 NZ_CP075140:4581175-4581459 [Salmonella enterica]
MQTTTRKSIRNKQINIRATDEERAVIDYAAKLVSKNRTDFIIEKAVNEAQNIILDQRVFVLDDARYQAFIEQLEAPVQNV
EGRQRLMDVKPEWK

Nucleotide

• Length: 285 bp

>AT203268 NZ_CP099906:1047111-1047343 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Structures

Antitoxin

• AlphaFold DB: A0A5Y0S3F2