Detailed information of TA system TA203267

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4302860..4303376
• Replicon: chromosome
• Accession: NZ_CP075140
• Organism: Salmonella enterica strain CFSAN044865

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V1HEI0
• Locus tag: A7R87_RS20670
• Protein ID: WP_000220584.1
• Coordinates: 4302860..4303144 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V1HDU1
• Locus tag: A7R87_RS20675
• Protein ID: WP_023182636.1
• Coordinates: 4303134..4303376 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7R87_RS20655 (4298001)	4298001..4299653	+	1653	WP_023248623.1	alpha,alpha-phosphotrehalase	-
A7R87_RS20660 (4300063)	4300063..4302201	+	2139	WP_023248624.1	anaerobic ribonucleoside-triphosphate reductase	-
A7R87_RS20665 (4302386)	4302386..4302850	+	465	WP_023248625.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
A7R87_RS20670 (4302860)	4302860..4303144	-	285	WP_000220584.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A7R87_RS20675 (4303134)	4303134..4303376	-	243	WP_023182636.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
A7R87_RS20680 (4303455)	4303455..4305368	-	1914	WP_023248626.1	BglG family transcription antiterminator	-
A7R87_RS20685 (4305385)	4305385..4306125	-	741	WP_070790078.1	KDGP aldolase family protein	-
A7R87_RS20690 (4306122)	4306122..4307240	-	1119	WP_023248628.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
A7R87_RS20695 (4307224)	4307224..4308357	-	1134	WP_023248629.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11085.02 Da
• Isoelectric Point: 10.3015

>T203267 WP_000220584.1 NZ_CP075140:c4303144-4302860 [Salmonella enterica]
MTYELEFDPRALKEWQKLGETVKKQFRKKLVDVLSNPRVESARLRELPDCYKIKLKTSGYRLVYQVQDDVVLVVVIAIGK
REKSAVYRQADKRL

Nucleotide

• Length: 285 bp

>T203267 NZ_CP099906:c755135-754749 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTTATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9013.38 Da
• Isoelectric Point: 5.0651

>AT203267 WP_023182636.1 NZ_CP075140:c4303376-4303134 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTVTISDSEDALLQTVRERLANPQKGIRVSLDDL

Nucleotide

• Length: 243 bp

>AT203267 NZ_CP099906:c755353-755132 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Structures

Toxin

• AlphaFold DB: A0A741MVA9