Detailed information of TA system TA203266

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 4162523..4163099
• Replicon: chromosome
• Accession: NZ_CP075140
• Organism: Salmonella enterica strain CFSAN044865

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: A0A8E9YCK2
• Locus tag: A7R87_RS19990
• Protein ID: WP_023247536.1
• Coordinates: 4162812..4163099 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: A0A8E9YD15
• Locus tag: A7R87_RS19985
• Protein ID: WP_023247535.1
• Coordinates: 4162523..4162825 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7R87_RS19970 (4159033)	4159033..4161183	+	2151	WP_023247533.1	pyruvate/proton symporter BtsT	-
A7R87_RS19975 (4161278)	4161278..4161481	+	204	WP_000460616.1	YbdD/YjiX family protein	-
A7R87_RS19980 (4161492)	4161492..4162448	+	957	WP_053507632.1	GTPase	-
A7R87_RS19985 (4162523)	4162523..4162825	-	303	WP_023247535.1	BrnA antitoxin family protein	Antitoxin
A7R87_RS19990 (4162812)	4162812..4163099	-	288	WP_023247536.1	BrnT family toxin	Toxin
A7R87_RS19995 (4163368)	4163368..4164282	-	915	WP_023247537.1	restriction endonuclease	-
A7R87_RS20000 (4164480)	4164480..4167989	+	3510	WP_053529526.1	type I restriction-modification system endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (32-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11312.77 Da
• Isoelectric Point: 8.5288

>T203266 WP_023247536.1 NZ_CP075140:c4163099-4162812 [Salmonella enterica]
MPMEFEWDANKAKSNLNKHGIRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGYEVIRIIS
TRKADRKERNRYEHG

Nucleotide

• Length: 288 bp

>T203266 NZ_CP099906:c732593-732315 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11397.04 Da
• Isoelectric Point: 10.3140

>AT203266 WP_023247535.1 NZ_CP075140:c4162825-4162523 [Salmonella enterica]
MSMVKHKRGNVPALSAQHEAELKALAKKSDDEIDYSDIPASENGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Nucleotide

• Length: 303 bp

>AT203266 NZ_CP099906:c732315-732031 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAGTAG