Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3654869..3655489 Replicon chromosome
Accession NZ_CP075140
Organism Salmonella enterica strain CFSAN044865

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag A7R87_RS17570 Protein ID WP_001280991.1
Coordinates 3655271..3655489 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag A7R87_RS17565 Protein ID WP_000344807.1
Coordinates 3654869..3655243 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7R87_RS17555 (3650006) 3650006..3651199 + 1194 WP_023246703.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
A7R87_RS17560 (3651222) 3651222..3654371 + 3150 WP_023246702.1 efflux RND transporter permease AcrB -
A7R87_RS17565 (3654869) 3654869..3655243 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
A7R87_RS17570 (3655271) 3655271..3655489 + 219 WP_001280991.1 HHA domain-containing protein Toxin
A7R87_RS17575 (3655669) 3655669..3656220 + 552 WP_053508533.1 maltose O-acetyltransferase -
A7R87_RS17580 (3656337) 3656337..3656807 + 471 WP_023246700.1 YlaC family protein -
A7R87_RS17585 (3656862) 3656862..3657002 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
A7R87_RS17590 (3657008) 3657008..3657268 - 261 WP_023182818.1 type B 50S ribosomal protein L31 -
A7R87_RS17595 (3657493) 3657493..3659043 + 1551 WP_023246699.1 EAL domain-containing protein -
A7R87_RS17605 (3659274) 3659274..3659663 + 390 WP_023246698.1 MGMT family protein -
A7R87_RS17610 (3659696) 3659696..3660265 - 570 WP_000779808.1 YbaY family lipoprotein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T203265 WP_001280991.1 NZ_CP075140:3655271-3655489 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T203265 NZ_CP099905:c65041-64625 [Escherichia albertii]
GTGAACAAGATCTATATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCACGTTCAGCTGGTTGACGCATTCTGTGAGCGACTCGATGCCGTCCTGCCCTGGGATCGCGCC
GCGGTGGATGCGACCACAGAGATTAAGGTGGCGCTGCGCCTCGCCGGAACGCCGATAGGCCCGAACGACACGGCGATTTC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTTCCGGGCCTGATACTGG
AAGACTGGGCCGGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT203265 WP_000344807.1 NZ_CP075140:3654869-3655243 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT203265 NZ_CP099905:c65268-65038 [Escherichia albertii]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGTGCCATCCGTCTGCCCCGGGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGGCAGCATCATCCTGCGTCCCGTCCGACCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTATCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4ICG


Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References