Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3654869..3655489 | Replicon | chromosome |
Accession | NZ_CP075140 | ||
Organism | Salmonella enterica strain CFSAN044865 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | V1H8E6 |
Locus tag | A7R87_RS17570 | Protein ID | WP_001280991.1 |
Coordinates | 3655271..3655489 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | V1H4V6 |
Locus tag | A7R87_RS17565 | Protein ID | WP_000344807.1 |
Coordinates | 3654869..3655243 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A7R87_RS17555 (3650006) | 3650006..3651199 | + | 1194 | WP_023246703.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
A7R87_RS17560 (3651222) | 3651222..3654371 | + | 3150 | WP_023246702.1 | efflux RND transporter permease AcrB | - |
A7R87_RS17565 (3654869) | 3654869..3655243 | + | 375 | WP_000344807.1 | Hha toxicity modulator TomB | Antitoxin |
A7R87_RS17570 (3655271) | 3655271..3655489 | + | 219 | WP_001280991.1 | HHA domain-containing protein | Toxin |
A7R87_RS17575 (3655669) | 3655669..3656220 | + | 552 | WP_053508533.1 | maltose O-acetyltransferase | - |
A7R87_RS17580 (3656337) | 3656337..3656807 | + | 471 | WP_023246700.1 | YlaC family protein | - |
A7R87_RS17585 (3656862) | 3656862..3657002 | - | 141 | WP_001197749.1 | type B 50S ribosomal protein L36 | - |
A7R87_RS17590 (3657008) | 3657008..3657268 | - | 261 | WP_023182818.1 | type B 50S ribosomal protein L31 | - |
A7R87_RS17595 (3657493) | 3657493..3659043 | + | 1551 | WP_023246699.1 | EAL domain-containing protein | - |
A7R87_RS17605 (3659274) | 3659274..3659663 | + | 390 | WP_023246698.1 | MGMT family protein | - |
A7R87_RS17610 (3659696) | 3659696..3660265 | - | 570 | WP_000779808.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8613.97 Da Isoelectric Point: 8.9008
>T203265 WP_001280991.1 NZ_CP075140:3655271-3655489 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T203265 NZ_CP099905:c65041-64625 [Escherichia albertii]
GTGAACAAGATCTATATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCACGTTCAGCTGGTTGACGCATTCTGTGAGCGACTCGATGCCGTCCTGCCCTGGGATCGCGCC
GCGGTGGATGCGACCACAGAGATTAAGGTGGCGCTGCGCCTCGCCGGAACGCCGATAGGCCCGAACGACACGGCGATTTC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTTCCGGGCCTGATACTGG
AAGACTGGGCCGGTTAG
GTGAACAAGATCTATATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCACGTTCAGCTGGTTGACGCATTCTGTGAGCGACTCGATGCCGTCCTGCCCTGGGATCGCGCC
GCGGTGGATGCGACCACAGAGATTAAGGTGGCGCTGCGCCTCGCCGGAACGCCGATAGGCCCGAACGACACGGCGATTTC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTTCCGGGCCTGATACTGG
AAGACTGGGCCGGTTAG
Antitoxin
Download Length: 125 a.a. Molecular weight: 14453.27 Da Isoelectric Point: 5.1444
>AT203265 WP_000344807.1 NZ_CP075140:3654869-3655243 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT203265 NZ_CP099905:c65268-65038 [Escherichia albertii]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGTGCCATCCGTCTGCCCCGGGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGGCAGCATCATCCTGCGTCCCGTCCGACCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTATCAGCGACGAAGGACGATTTAACCTGTGA
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGTGCCATCCGTCTGCCCCGGGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGGCAGCATCATCCTGCGTCCCGTCCGACCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTATCAGCGACGAAGGACGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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