Detailed information of TA system TA203264

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 3228990..3229637
• Replicon: chromosome
• Accession: NZ_CP075140
• Organism: Salmonella enterica strain CFSAN044865

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A8E9YA31
• Locus tag: A7R87_RS15450
• Protein ID: WP_023246826.1
• Coordinates: 3228990..3229172 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A8F0CEZ4
• Locus tag: A7R87_RS15455
• Protein ID: WP_023246827.1
• Coordinates: 3229203..3229637 (+)
• Length: 145 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7R87_RS15420 (3224712)	3224712..3225065	-	354	WP_023248686.1	DUF1353 domain-containing protein	-
A7R87_RS15425 (3225066)	3225066..3226088	-	1023	WP_023248687.1	hypothetical protein	-
A7R87_RS15430 (3226098)	3226098..3226331	-	234	WP_023247427.1	hypothetical protein	-
A7R87_RS15435 (3226400)	3226400..3226921	-	522	WP_070790296.1	hypothetical protein	-
A7R87_RS24585 (3226921)	3226921..3227166	-	246	WP_230316504.1	tail fiber domain-containing protein	-
A7R87_RS24590 (3227269)	3227269..3227658	-	390	Protein_3054	collagen-like protein	-
A7R87_RS15445 (3228589)	3228589..3228903	-	315	Protein_3055	prophage tail fiber N-terminal domain-containing protein	-
A7R87_RS15450 (3228990)	3228990..3229172	+	183	WP_023246826.1	type II toxin-antitoxin system HicA family toxin	Toxin
A7R87_RS15455 (3229203)	3229203..3229637	+	435	WP_023246827.1	hypothetical protein	Antitoxin
A7R87_RS15460 (3229660)	3229660..3230412	-	753	WP_070790279.1	hypothetical protein	-
A7R87_RS15465 (3230412)	3230412..3230768	-	357	WP_023246893.1	hypothetical protein	-
A7R87_RS15470 (3230778)	3230778..3233996	-	3219	WP_070795157.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3222898..3273669	50771

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (20-82)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6932.12 Da
• Isoelectric Point: 11.0888

>T203264 WP_023246826.1 NZ_CP075140:3228990-3229172 [Salmonella enterica]
MKYNEFRRWLIRQGAKFINAPGGGSHQRVILNGRESVFPYHGAKEIPEPLRKKILKDLGL

Nucleotide

• Length: 183 bp

>T203264 NZ_CP099904:77377-77757 [Escherichia albertii]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 145 a.a.
• Molecular weight: 15663.04 Da
• Isoelectric Point: 5.1799

>AT203264 WP_023246827.1 NZ_CP075140:3229203-3229637 [Salmonella enterica]
MFNYAVKLEHDPDTKSWIATCRDLPLFNSVGDSVDDALLESVDGAIVALSIEIDARRPIPAASQPEEGEYVIHLPVLVVM
KAALHNAMIATGTRKSDLARSMGMKGPQIDRLLDVCHSSKVETVELALQQLNRTVQISVNKVAA

Nucleotide

• Length: 435 bp

>AT203264 NZ_CP099904:77156-77377 [Escherichia albertii]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA