Detailed information of TA system TA203255

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 857995..858655
• Replicon: chromosome
• Accession: NZ_CP075140
• Organism: Salmonella enterica strain CFSAN044865

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8E9YGN6
• Locus tag: A7R87_RS04300
• Protein ID: WP_023249207.1
• Coordinates: 858242..858655 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: A7R87_RS04295
• Protein ID: WP_000351186.1
• Coordinates: 857995..858261 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7R87_RS04275 (853936)	853936..855369	-	1434	WP_023249203.1	6-phospho-beta-glucosidase BglA	-
A7R87_RS04280 (855527)	855527..855838	+	312	WP_023249204.1	N(4)-acetylcytidine aminohydrolase	-
A7R87_RS04285 (856002)	856002..856661	+	660	WP_023249205.1	hemolysin III family protein	-
A7R87_RS04290 (856762)	856762..857742	-	981	WP_023249206.1	tRNA-modifying protein YgfZ	-
A7R87_RS04295 (857995)	857995..858261	+	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
A7R87_RS04300 (858242)	858242..858655	+	414	WP_023249207.1	protein YgfX	Toxin
A7R87_RS04305 (858707)	858707..859228	-	522	WP_023249208.1	flavodoxin FldB	-
A7R87_RS04310 (859341)	859341..860237	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
A7R87_RS04315 (860261)	860261..860974	+	714	WP_070788883.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
A7R87_RS04320 (860980)	860980..862716	+	1737	WP_023249210.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16283.31 Da
• Isoelectric Point: 11.4501

>T203255 WP_023249207.1 NZ_CP075140:858242-858655 [Salmonella enterica]
VVLWQSELRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLRSGMVLRLRAESGHHQHLWLAADSMEAAEWRELRRIMLQQPISRQH

Nucleotide

• Length: 414 bp

>T203255 NZ_CP099903:2453657-2454043 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTTATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCTGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT203255 WP_000351186.1 NZ_CP075140:857995-858261 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT203255 NZ_CP099903:2453439-2453660 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A5I0YWH4