Detailed information of TA system TA203254

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 667357..667930
• Replicon: chromosome
• Accession: NZ_CP075140
• Organism: Salmonella enterica strain CFSAN044865

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A8E9YDY4
• Locus tag: A7R87_RS03310
• Protein ID: WP_023246565.1
• Coordinates: 667357..667653 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: A7R87_RS03315
• Protein ID: WP_023246564.1
• Coordinates: 667655..667930 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7R87_RS03285 (662861)	662861..663157	+	297	WP_023246570.1	DUF4222 domain-containing protein	-
A7R87_RS03290 (663154)	663154..665304	+	2151	WP_108418457.1	DUF927 domain-containing protein	-
A7R87_RS03295 (665707)	665707..666162	+	456	WP_023246568.1	single-stranded DNA-binding protein	-
A7R87_RS03300 (666216)	666216..666815	+	600	WP_023246567.1	ProQ/FinO family protein	-
A7R87_RS03305 (666805)	666805..667017	+	213	WP_070788861.1	hypothetical protein	-
A7R87_RS03310 (667357)	667357..667653	+	297	WP_023246565.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A7R87_RS03315 (667655)	667655..667930	+	276	WP_023246564.1	putative addiction module antidote protein	Antitoxin
A7R87_RS03320 (667967)	667967..668305	+	339	WP_227005394.1	transcriptional regulator	-
A7R87_RS03325 (668388)	668388..668579	-	192	WP_070793605.1	hypothetical protein	-
A7R87_RS03330 (668823)	668823..669167	+	345	WP_023246561.1	single-stranded DNA-binding protein	-
A7R87_RS03335 (669649)	669649..670038	-	390	WP_070788863.1	hypothetical protein	-
A7R87_RS03340 (670963)	670963..671163	+	201	WP_077918424.1	hypothetical protein	-
A7R87_RS24315 (671286)	671286..671870	+	585	WP_070788864.1	FimD/PapC N-terminal domain-containing protein	-
A7R87_RS03350 (672052)	672052..672531	+	480	WP_070788865.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	657327..667930	10603

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (45-89)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11083.88 Da
• Isoelectric Point: 10.3907

>T203254 WP_023246565.1 NZ_CP075140:667357-667653 [Salmonella enterica]
MIDIKTTPEAEKWLKGLKDRVAKSKILIRIDRMRTGNFGDVEPVGGGLSELRIHHGKGYRVYFGNKNNEIILILCGGDKS
TQQDDIQKAKQIAKKWGF

Nucleotide

• Length: 297 bp

>T203254 NZ_CP099903:2385376-2385663 [Escherichia albertii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10035.38 Da
• Isoelectric Point: 4.7683

>AT203254 WP_023246564.1 NZ_CP075140:667655-667930 [Salmonella enterica]
MKQVLKDFDVADYLEDEDDVIAYLNAVIAEGDNKQLFIALGNIARARNISRISKETGISREGIYKALSGDGNPSFNTLSK
ITKAMGLDLHF

Nucleotide

• Length: 276 bp

>AT203254 NZ_CP099903:2385137-2385376 [Escherichia albertii]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA