Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 471195..471768 Replicon chromosome
Accession NZ_CP075140
Organism Salmonella enterica strain CFSAN044865

Toxin (Protein)


Gene name PumA Uniprot ID A0A8E9YDY4
Locus tag A7R87_RS02310 Protein ID WP_023246565.1
Coordinates 471195..471491 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag A7R87_RS02315 Protein ID WP_023246564.1
Coordinates 471493..471768 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7R87_RS02285 (468143) 468143..469123 + 981 WP_070793603.1 tyrosine-type recombinase/integrase -
A7R87_RS02290 (469261) 469261..469554 + 294 WP_070793602.1 hypothetical protein -
A7R87_RS02295 (469551) 469551..470000 + 450 WP_070793601.1 single-stranded DNA-binding protein -
A7R87_RS02300 (470054) 470054..470653 + 600 WP_258229873.1 ProQ/FinO family protein -
A7R87_RS02305 (470643) 470643..470855 + 213 WP_023246566.1 hypothetical protein -
A7R87_RS02310 (471195) 471195..471491 + 297 WP_023246565.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7R87_RS02315 (471493) 471493..471768 + 276 WP_023246564.1 putative addiction module antidote protein Antitoxin
A7R87_RS02320 (471805) 471805..472143 + 339 WP_227005394.1 transcriptional regulator -
A7R87_RS02325 (472226) 472226..472417 - 192 WP_070793605.1 hypothetical protein -
A7R87_RS02330 (472661) 472661..473005 + 345 WP_023246561.1 single-stranded DNA-binding protein -
A7R87_RS02335 (473487) 473487..473876 - 390 WP_070803629.1 hypothetical protein -
A7R87_RS24305 (474651) 474651..474833 + 183 WP_023246326.1 hypothetical protein -
A7R87_RS02345 (475097) 475097..475252 + 156 WP_154707550.1 hypothetical protein -
A7R87_RS02350 (475505) 475505..476239 + 735 WP_170826680.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 456266..485532 29266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-89)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11083.88 Da        Isoelectric Point: 10.3907

>T203253 WP_023246565.1 NZ_CP075140:471195-471491 [Salmonella enterica]
MIDIKTTPEAEKWLKGLKDRVAKSKILIRIDRMRTGNFGDVEPVGGGLSELRIHHGKGYRVYFGNKNNEIILILCGGDKS
TQQDDIQKAKQIAKKWGF

Download         Length: 297 bp

>T203253 NZ_CP099903:2105506-2105608 [Escherichia albertii]
GCAAGGCAACTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAACA
GGAATCGTTTTCGGTCTCTTTTT

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10035.38 Da        Isoelectric Point: 4.7683

>AT203253 WP_023246564.1 NZ_CP075140:471493-471768 [Salmonella enterica]
MKQVLKDFDVADYLEDEDDVIAYLNAVIAEGDNKQLFIALGNIARARNISRISKETGISREGIYKALSGDGNPSFNTLSK
ITKAMGLDLHF

Download         Length: 276 bp

>AT203253 NZ_CP099903:c2105610-2105378 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTCAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References