Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4352196..4352977 Replicon chromosome
Accession NZ_CP075138
Organism Salmonella enterica strain CFSAN044875

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A752VN12
Locus tag A7R97_RS21345 Protein ID WP_000622305.1
Coordinates 4352196..4352687 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag A7R97_RS21350 Protein ID WP_001110453.1
Coordinates 4352684..4352977 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7R97_RS21300 (4347291) 4347291..4347377 + 87 Protein_4195 porin family protein -
A7R97_RS21305 (4347468) 4347468..4348220 + 753 WP_000842407.1 non-specific acid phosphatase -
A7R97_RS21310 (4348365) 4348365..4349213 - 849 WP_001627551.1 SdiA-regulated domain-containing protein -
A7R97_RS21315 (4349239) 4349239..4349400 - 162 WP_001816720.1 hypothetical protein -
A7R97_RS21320 (4349661) 4349661..4349837 - 177 WP_139782396.1 FaeA/PapI family transcriptional regulator -
A7R97_RS21325 (4350439) 4350439..4350642 - 204 Protein_4200 transcriptional regulator -
A7R97_RS21330 (4351231) 4351231..4351488 + 258 WP_001112996.1 hypothetical protein -
A7R97_RS21335 (4351526) 4351526..4351681 - 156 WP_161485944.1 hypothetical protein -
A7R97_RS21340 (4351733) 4351733..4351981 - 249 Protein_4203 IS481 family transposase -
A7R97_RS21345 (4352196) 4352196..4352687 - 492 WP_000622305.1 GNAT family N-acetyltransferase Toxin
A7R97_RS21350 (4352684) 4352684..4352977 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
A7R97_RS24660 (4353295) 4353295..4353517 + 223 Protein_4206 hypothetical protein -
A7R97_RS21355 (4353781) 4353781..4354656 + 876 WP_000921676.1 AraC family transcriptional regulator -
A7R97_RS21360 (4354653) 4354653..4354940 + 288 WP_076018242.1 transcriptional regulator RtsB -
A7R97_RS24665 (4354933) 4354933..4355115 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
A7R97_RS24670 (4355135) 4355135..4355234 + 100 Protein_4210 hypothetical protein -
A7R97_RS24675 (4355345) 4355345..4355479 + 135 Protein_4211 hypothetical protein -
A7R97_RS21370 (4355774) 4355774..4356679 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T203250 WP_000622305.1 NZ_CP075138:c4352687-4352196 [Salmonella enterica]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T203250 NZ_CP099903:890053-890457 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT203250 WP_001110453.1 NZ_CP075138:c4352977-4352684 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT203250 NZ_CP099903:889806-890072 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGTCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A752VN12

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References