Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4241612..4242128 Replicon chromosome
Accession NZ_CP075137
Organism Salmonella enterica strain CFSAN044885

Toxin (Protein)


Gene name relE Uniprot ID A0A5I6CHB9
Locus tag A7S07_RS20510 Protein ID WP_000220581.1
Coordinates 4241612..4241896 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag A7S07_RS20515 Protein ID WP_000212724.1
Coordinates 4241886..4242128 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S07_RS20495 (4236728) 4236728..4238380 + 1653 WP_070793923.1 alpha,alpha-phosphotrehalase -
A7S07_RS20500 (4238789) 4238789..4240927 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
A7S07_RS20505 (4241144) 4241144..4241608 + 465 WP_001009175.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A7S07_RS20510 (4241612) 4241612..4241896 - 285 WP_000220581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7S07_RS20515 (4241886) 4241886..4242128 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A7S07_RS20520 (4242206) 4242206..4244119 - 1914 WP_023216476.1 BglG family transcription antiterminator -
A7S07_RS20525 (4244136) 4244136..4244876 - 741 WP_000779254.1 KDGP aldolase family protein -
A7S07_RS20530 (4244873) 4244873..4245991 - 1119 WP_023216475.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
A7S07_RS20535 (4245975) 4245975..4247108 - 1134 WP_023216474.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T203231 WP_000220581.1 NZ_CP075137:c4241896-4241612 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T203231 NZ_CP099898:166179-166331 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT203231 WP_000212724.1 NZ_CP075137:c4242128-4241886 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT203231 NZ_CP099898:c166122-166074 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References