Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4200951..4201501 Replicon chromosome
Accession NZ_CP075137
Organism Salmonella enterica strain CFSAN044885

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag A7S07_RS20300 Protein ID WP_001199743.1
Coordinates 4200951..4201259 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag A7S07_RS20305 Protein ID WP_000016244.1
Coordinates 4201262..4201501 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S07_RS20280 (4197663) 4197663..4198442 - 780 WP_023216488.1 HNH endonuclease -
A7S07_RS23745 (4198603) 4198603..4198761 + 159 WP_023216487.1 hypothetical protein -
A7S07_RS20295 (4200269) 4200269..4200519 - 251 Protein_3987 Arm DNA-binding domain-containing protein -
A7S07_RS20300 (4200951) 4200951..4201259 - 309 WP_001199743.1 CcdB family protein Toxin
A7S07_RS20305 (4201262) 4201262..4201501 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
A7S07_RS20310 (4201610) 4201610..4201858 - 249 WP_000254751.1 ribbon-helix-helix domain-containing protein -
A7S07_RS20320 (4202049) 4202049..4202480 - 432 Protein_3991 helix-turn-helix domain-containing protein -
A7S07_RS20330 (4203238) 4203238..4204257 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
A7S07_RS20335 (4204285) 4204285..4204815 - 531 WP_000896756.1 gluconokinase -
A7S07_RS20340 (4205032) 4205032..4206063 + 1032 WP_023216483.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4198977..4202435 3458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T203230 WP_001199743.1 NZ_CP075137:c4201259-4200951 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T203230 NZ_CP099898:142032-142217 [Escherichia albertii]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT203230 WP_000016244.1 NZ_CP075137:c4201501-4201262 [Salmonella enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT203230 NZ_CP099898:142234-142644 [Escherichia albertii]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGGGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTTCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGGTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References