Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3528903..3529523 Replicon chromosome
Accession NZ_CP075137
Organism Salmonella enterica strain CFSAN044885

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag A7S07_RS17255 Protein ID WP_001280991.1
Coordinates 3529305..3529523 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag A7S07_RS17250 Protein ID WP_000344807.1
Coordinates 3528903..3529277 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S07_RS17240 (3524042) 3524042..3525235 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
A7S07_RS17245 (3525258) 3525258..3528407 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
A7S07_RS17250 (3528903) 3528903..3529277 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
A7S07_RS17255 (3529305) 3529305..3529523 + 219 WP_001280991.1 HHA domain-containing protein Toxin
A7S07_RS17260 (3529702) 3529702..3530253 + 552 WP_001278793.1 maltose O-acetyltransferase -
A7S07_RS17265 (3530370) 3530370..3530840 + 471 WP_000136183.1 YlaC family protein -
A7S07_RS17270 (3530896) 3530896..3531036 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
A7S07_RS17275 (3531042) 3531042..3531302 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
A7S07_RS17280 (3531527) 3531527..3533077 + 1551 WP_000213145.1 EAL domain-containing protein -
A7S07_RS17290 (3533308) 3533308..3533697 + 390 WP_000961285.1 MGMT family protein -
A7S07_RS17295 (3533730) 3533730..3534299 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T203226 WP_001280991.1 NZ_CP075137:3529305-3529523 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T203226 NZ_CP099896:3014-3535 [Escherichia albertii]
GTGAGCAATACAACGATAGAGATTTTCTCTGGAGAGAAAGATTATGATCTAAACGGTTTTGATTGCGGCGAAGAGTCACT
AAACGCCTTTTTAGCCAACCACTTAAAAAGGCAGCATGAGGGAAAAATTCTTCGTGCTTATGTGCTTTGCACTCAAGAAG
AAAGGCCAAAAGTGTTAGGATATTACACTTTGTCAGGTAGTTGTTTTGAAAAGGAGTCCTTACCTTCAAGAAGCAAACAA
AAGAAGGTTCCTTATCGGAATGTTCCAAGTGTTACTTTGGGTAGGCTGGCTTTGGACAAGTCCCTTCAAGGTCAAGGATT
TGGCTCAATGCTTGTAACACATGCAATGCGCGTTGTGTACAATGCATCTCTTGCTGTAGGCATTCATGGACTTTTCGTTG
AGGCGTTAAATGACAAAGCCAAGGCGTTTTATAAAAGTTTAGGCTTTATCCAGCTGGTTGGTAACAACGAGCGTTCTTTG
TTCTATCCTACAAAATCTATCGAAAAATTGTTCGAAGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT203226 WP_000344807.1 NZ_CP075137:3528903-3529277 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT203226 NZ_CP099896:2737-3006 [Escherichia albertii]
ATGTCAGCACTAAAAAAGCAGCGCATCGATTTGAGATTAACCGATGACGATAAAAGCATCATCGAGGAAGCTGCCGCAAT
GTCTAACCAGAGCATTACTCAGTTTATGGTTAGCAGTGCATCTGAACGTGCCGTGAAAGTTATAGAGCAACACCGTAGAC
TAGTTCTGAATGAAGAATCCTGGAATCTGGTTATGGACGCTATAAGCAATCCTCCGGCACCGAACGACAAGCTGAAACGA
GCTGCTGATCGTCTGAAAAGCATGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References