Detailed information of TA system TA203215

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1017089..1017903
• Replicon: chromosome
• Accession: NZ_CP075137
• Organism: Salmonella enterica strain CFSAN044885

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E7N5G9
• Locus tag: A7S07_RS04865
• Protein ID: WP_023216105.1
• Coordinates: 1017089..1017616 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: A7S07_RS04870
• Protein ID: WP_000855694.1
• Coordinates: 1017613..1017903 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S07_RS04835 (1013290)	1013290..1013688	+	399	Protein_947	cytoplasmic protein	-
A7S07_RS04840 (1013879)	1013879..1014118	+	240	Protein_948	hypothetical protein	-
A7S07_RS04845 (1014275)	1014275..1014943	+	669	WP_023216104.1	hypothetical protein	-
A7S07_RS04850 (1014970)	1014970..1015464	+	495	WP_000424946.1	hypothetical protein	-
A7S07_RS04855 (1015709)	1015709..1016365	-	657	WP_017441135.1	protein-serine/threonine phosphatase	-
A7S07_RS04860 (1016592)	1016592..1017016	+	425	Protein_952	transposase	-
A7S07_RS04865 (1017089)	1017089..1017616	-	528	WP_023216105.1	GNAT family N-acetyltransferase	Toxin
A7S07_RS04870 (1017613)	1017613..1017903	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
A7S07_RS04875 (1018173)	1018173..1018373	-	201	Protein_955	transposase	-
A7S07_RS04880 (1018777)	1018777..1019220	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
A7S07_RS04885 (1019676)	1019676..1020326	+	651	WP_023166786.1	type III secretion system transcriptional activator InvF	-
A7S07_RS04890 (1020323)	1020323..1022011	+	1689	WP_000848101.1	type III secretion system outer membrane ring protein InvG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1016792..1025639	8847
	-	flank	IS/Tn	-	-	1016792..1017016	224

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19066.94 Da
• Isoelectric Point: 9.4012

>T203215 WP_023216105.1 NZ_CP075137:c1017616-1017089 [Salmonella enterica]
MMFTDWHEAAIGKIHNRMNFDCGDADLNQFLQRHARQNHEIGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T203215 NZ_CP099895:635438-635752 [Escherichia albertii]
ATGCACCTGATCACTCAAAAAGCATTGAAAGATGCAGCGGAAAAATATCCGCAGCATAAAACGGAGTTGGTGGCACTGGG
GAACACGATTGCTAAGGGATACTTCAAAAAACCTGAGTCATTAAAAGCAGTGTTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCACAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT203215 WP_000855694.1 NZ_CP075137:c1017903-1017613 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT203215 NZ_CP099895:635749-636165 [Escherichia albertii]
ATGATTGCGATTGCCGATATCTTGCAAGCAGGAGAAAAGCTAACCGATGTGGCACCTTTTCTGGCGGGTATCCAGAGCGA
AGAACAGTATGCCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCGATGGTTCAAGCCATGCCTGGCGGT
GTTGCTGTGATTCGTACCCTGATGGATCAATACGGCTTAACCCTTTCCGATCTTCCAGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAACGGGAAGAGAAAATTAACGCTGGAACACGCTAAAAAACTGGCAGCGCGATTCGGCATTTCCCCTG
CGTTGTTTATTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7