Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 225487..226247 Replicon chromosome
Accession NZ_CP075137
Organism Salmonella enterica strain CFSAN044885

Toxin (Protein)


Gene name tacT Uniprot ID A0A8E7JZU9
Locus tag A7S07_RS01050 Protein ID WP_023216228.1
Coordinates 225762..226247 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag A7S07_RS01045 Protein ID WP_000965889.1
Coordinates 225487..225774 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S07_RS23510 (221915) 221915..222343 + 429 Protein_204 IS3 family transposase -
A7S07_RS01035 (222539) 222539..223309 - 771 WP_000456879.1 DUF3800 domain-containing protein -
A7S07_RS23515 (224336) 224336..225364 + 1029 WP_023196719.1 HNH endonuclease signature motif containing protein -
A7S07_RS01045 (225487) 225487..225774 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
A7S07_RS01050 (225762) 225762..226247 + 486 WP_023216228.1 GNAT family N-acetyltransferase Toxin
A7S07_RS01055 (226618) 226618..227157 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
A7S07_RS01060 (227330) 227330..227542 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
A7S07_RS01065 (227830) 227830..228120 - 291 WP_000455790.1 HTH-type transcriptional regulator -
A7S07_RS01070 (228559) 228559..229269 + 711 WP_000190524.1 DUF3053 domain-containing protein -
A7S07_RS01075 (229319) 229319..230293 - 975 WP_023216229.1 glyoxylate/hydroxypyruvate reductase GhrB -
A7S07_RS01080 (230512) 230512..231174 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17685.37 Da        Isoelectric Point: 9.8719

>T203212 WP_023216228.1 NZ_CP075137:225762-226247 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNI
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T203212 NZ_CP099895:166286-166438 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT203212 WP_000965889.1 NZ_CP075137:225487-225774 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT203212 NZ_CP099895:c166229-166181 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References