Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4386703..4387484 Replicon chromosome
Accession NZ_CP075135
Organism Salmonella enterica strain CFSAN044888

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag A7S10_RS21420 Protein ID WP_000625912.1
Coordinates 4386703..4387194 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag A7S10_RS21425 Protein ID WP_001110450.1
Coordinates 4387191..4387484 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S10_RS21385 (4382114) 4382114..4382461 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
A7S10_RS21390 (4382437) 4382437..4384140 + 1704 WP_000068889.1 protein-disulfide reductase DsbD -
A7S10_RS21395 (4384177) 4384177..4384752 + 576 WP_001188509.1 transcriptional regulator -
A7S10_RS21405 (4385023) 4385023..4385097 - 75 Protein_4217 helix-turn-helix domain-containing protein -
A7S10_RS21410 (4385477) 4385477..4385554 + 78 Protein_4218 porin family protein -
A7S10_RS21415 (4385654) 4385654..4386406 + 753 WP_070794150.1 non-specific acid phosphatase -
A7S10_RS21420 (4386703) 4386703..4387194 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
A7S10_RS21425 (4387191) 4387191..4387484 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
A7S10_RS23995 (4387801) 4387801..4388010 + 210 Protein_4222 hypothetical protein -
A7S10_RS21430 (4388274) 4388274..4389149 + 876 WP_000921676.1 AraC family transcriptional regulator -
A7S10_RS21435 (4389146) 4389146..4389433 + 288 WP_001269916.1 transcriptional regulator RtsB -
A7S10_RS24000 (4389426) 4389426..4389608 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
A7S10_RS24005 (4389632) 4389632..4389832 + 201 WP_240494974.1 hypothetical protein -
A7S10_RS24010 (4389837) 4389837..4389971 + 135 Protein_4227 hypothetical protein -
A7S10_RS21445 (4390266) 4390266..4391171 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T203207 WP_000625912.1 NZ_CP075135:c4387194-4386703 [Salmonella enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T203207 NZ_CP099892:c4033281-4032904 [Escherichia albertii]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGTCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT203207 WP_001110450.1 NZ_CP075135:c4387484-4387191 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT203207 NZ_CP099892:c4033739-4033371 [Escherichia albertii]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References