Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4246339..4246855 Replicon chromosome
Accession NZ_CP075135
Organism Salmonella enterica strain CFSAN044888

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag A7S10_RS20595 Protein ID WP_000220578.1
Coordinates 4246339..4246623 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag A7S10_RS20600 Protein ID WP_000212724.1
Coordinates 4246613..4246855 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S10_RS20580 (4241455) 4241455..4243107 + 1653 WP_000155035.1 alpha,alpha-phosphotrehalase -
A7S10_RS20585 (4243516) 4243516..4245654 + 2139 WP_000187815.1 anaerobic ribonucleoside-triphosphate reductase -
A7S10_RS20590 (4245871) 4245871..4246335 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A7S10_RS20595 (4246339) 4246339..4246623 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7S10_RS20600 (4246613) 4246613..4246855 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A7S10_RS20605 (4246933) 4246933..4248846 - 1914 WP_001212131.1 BglG family transcription antiterminator -
A7S10_RS20610 (4248863) 4248863..4249603 - 741 WP_000779263.1 KDGP aldolase family protein -
A7S10_RS20615 (4249600) 4249600..4250718 - 1119 WP_001139184.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
A7S10_RS20620 (4250702) 4250702..4251835 - 1134 WP_001636647.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T203206 WP_000220578.1 NZ_CP075135:c4246623-4246339 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T203206 NZ_CP099892:3992304-3992645 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCACCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTAATTAC
AGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT203206 WP_000212724.1 NZ_CP075135:c4246855-4246613 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT203206 NZ_CP099892:c3992309-3992233 [Escherichia albertii]
AGTCATGATTACTATTCTCCATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References